Children 10-16 years: Usual range, 6-7 mg/kg/day IV/orally divided two to three times daily Dosing Considerations Children under 6 years: Potential toxic dose, 20 mg/kg Therapeutic range: 10-20 mcg/L (total) or 1-2 mcg/L free drug ALWAYS administer intravenous (IV) slowly; not to ...
One of the major limitations with the clinical use of phenytoin is its capacity of saturating the metabolic pathways at serum concentration within the therapeutic range of 10–20 μg/mL. The elimination of phenytoin follows a dose-dependent, nonlinear kinetics (Michaelis–Menten) model, which can...
A therapeutic serum level of PHT was maintained in all four patients. Another group of three patients received PHT suspension, at an interval of 8 h, with water at room temperature. Again serum PHT levels were maintained in the therapeutic range in all three patients. The present preliminary ...
A therapeutic serum level of PHT was maintained in all four patients. Another group of three patients received PHT suspension, at an interval of 8 h, with water at room temperature. Again serum PHT levels were maintained in the therapeutic range in all three patients. The present preliminary ...
Phenytoin may also raise the serum glucose level in diabetic patients. Serum Phenytoin Levels Above Therapeutic Range Serum levels of phenytoin sustained above the therapeutic range may produce confusional states referred to as “delirium,”“psychosis,” or “encephalopathy,” or rarely irreversible ...
Phenytoin was stopped until values were within the therapeutic range and then restarted at a lower dose, tacrolimus therapy continuing throughout; phenytoin levels re- mained stable thereafter. For the effect of phenytoin on ciclosporin, see p.1826. 1. Thompson PA, Mosley CA. Tacrolimus-phenytoin...
Ten healthy adult subjects took a single daily dose of phenytoin for 9 days to achieve a steady-state serum phenytoin concentration in the therapeutic range. While continuing on phenytoin, subjects took increasing doses of salicylate in a step-wise fashion, each dose (325, 650, and 975 mg) ...
776-81. 2. cooper tw, bauer ea. therapeutic efficacy of phenytoin in recessive dystrophic epidermolysis. arch dermatoli984; 120: 490-5. 3. scheinfeld n. phenytoin in cutaneous medicine: its uses, mechanisms and side effects. demwtol online j 2003; 9: 6. 4. caldwell-brown d, et a!. ...
Introduction Phenytoin is a first-line anticonvulsant used for status epilepticus and neurosurgery prophylaxis. It is highly protein bound (about 90%), primarily to albumin. It has a narrow therapeutic range and has non-linear pharmacokinetics. A guideline on safe prescribing, administration and ...
which typically have depolarized membrane potentials. At a concentration within the therapeutic range used to treat epilepsy, phenytoin significantly inhibited the migration and invasion of MDA-MB-231 cells, but had no effect on weakly metastatic MCF-7 cells, which do not express Na+currents. We ...