1979. The therapeutic range for Phenytoin—a reappraisal. Ir. J. Med. Sci. 148, 44–49. View ArticleFeely M, Duggan B, O'Callaghan M, Callaghan N. The therapeutic range for phenytoin: a reappraisal. Ir J Med Sci 1979;2:44-9.
At a concentration within the therapeutic range used to treat epilepsy, phenytoin significantly inhibited the migration and invasion of MDA-MB-231 cells, but had no effect on weakly metastatic MCF-7 cells, which do not express Na currents. We conclude that phenytoin suppresses ...
more specific assay techniques, but the accepted range is very dependent on the type of assay. There is wide interindividual variability in the optimal drug concentration with toxicity occurring from 3μg/ml.
At a concentration within the therapeutic range used to treat epilepsy, phenytoin significantly inhibited the migration and invasion of MDA-MB-231 cells, but had no effect on weakly metastatic MCF-7 cells, which do not express Na(+) currents. We conclude that phenytoin suppresses Na(+) current...
Phenytoin (PHT) is a first line antiepileptic drug (AED) used to treat many epilepsy syndromes. As with other AEDs, there are various adverse effects associated with PHT. For this brief review, we searched for evidence of cerebellar ataxia as a chronic adverse effect of therapeutic-range PHT ...
The drugs described are: acecainide (n-acetylprocainamide), digoxin, digitoxin, procainamide, quinidine, theophylline, amikacin, gentamicin, tobramycin, vancomycin, carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin (diphenylhydantoin), primidone, topiramate, valproic acid, ...
A therapeutic serum level of phenytoin (PHT) is difficult to achieve in patients who receive enteral tube feeding. In four patients, PHT capsules were dissolved in 250 ml warm water and cooled to body temperature before being administered. A therapeutic serum level of PHT was maintained in all...
Phenytoin (diphenylhydantoin) is still the most commonly used anticonvulsant drug. It has certain physicochemical characteristics which make it liable to bioavailability problems. Due to the dose dependent metabolism of phenytoin and to its narrow therapeutic range even small changes in the bioavailability...
therapeutic range used to treat epilepsy, phenytoin significantly inhibited the migration and invasion of MDA-MB-231 cells, but had no effect on weakly metastatic MCF-7 cells, which do not express Na+currents. We conclude that phenytoin suppresses Na+current in VGSC-expressing metastatic BCa cells...
phenytoin gentamicin amphotericin 5-fluoro-urocil zidovudine Therapeutic drug monitoring therapeutic window (TW) is the range of drug concentrations in which a drug is effective TW concept is reflected in TI calculation TW = MTC/MEC Minimum effective concentration (MEC) is the minimum...