we next tested the effect of a widely used VGSC-blocking anticonvulsant drug, phenytoin (50 μM), on Na+current in BCa cells, using whole-cell patch clamp recording. This concentration is within the serum therapeutic range used in clinical settings for treatment of epilepsy (10–20 μg/ml)...
Therapeutic drug monitoring of phenytoin is carried out to ensure effective and safe levels. Some of the factors complicating phenytoin dosing include a narrow therapeutic window, high degree of protein binding, and nonlinear pharmacokinetics. However, serum drug levels should only be taken when there...
Detection of the antiepileptic drug phenytoin using a single free-standing piezoresistive microcantilever for therapeutic drug monitoring Phenytoin, one of the most widely used antiepilept LS Huang,Y Pheanpanitporn,YK Yen,... - Biosensors & Bioelectronics: The International Journal for the Professional...
Therapeutic drug monitoring has come of age in clinical medicine and, in particular, its use with antiarrhythmic agents has flourished. The classic indications for the use of therapeutic drug monitoring are commonly encountered with antiarrhythmic drug use. Most of the currently available antiarrhythmics...
BackgroundTherapeutic drug monitoring of phenytoin by measurement of plasma concentrations is often employed to optimize clinical efficacy while avoiding a... KLE Penrod - 《Bmc Medical Informatics & Decision Making》 被引量: 13发表: 2012年 PREPARATION OF ALBUMIN FOR THERAPEUTIC USE PREPARATION OF ALB...
Prescription containing more than 3 drugs decreased while those with only one drug increased. Phenobarbital in monopharmacy therapy shifted to valproic acid. In polypharmacy therapy, phenytoin was mainly prescribed. In polypharmacy therapy, the prescription rate of phenobarbital or primidone decreased, ...
The pain most often occurs in the hands and feet and has been described as agonizing, burning, tingling, and lancinating.76 Neuropathic pain due to Fabry dis- ease is often managed with anticonvulsant drugs (e.g., carbam- azepine or phenytoin),77 because conventional analgesics and narcotic ...
Therapeutic drug monitoring is now widely used in many areas of medicine. With its proliferation has come an understanding of the clinical situations in wh
The observation that drug concentrations in saliva are often proportional to the concentrations in plasma has led to the suggestion that in therapeutic dru
P<0.01 compared to VPA). The epileptiform activities in both treatment recovered during drug washout (n=5 for each drug). (h) Comparison of the mean frequency of low Mg2+-induced burst discharges for the last 10 min during drug application with different treatments, demonstrating a significant...