Continuous administration of HLA-G1 ameliorated the AD-like skin lesions in the mice. Furthermore, production of immunoglobulin E, interleukin (IL)-13, and IL-17A was significantly reduced in HLA-G1-treated mice, suggesting a Th2/Th17-mediated immune-inhibitory function of HLA-G1 in vivo ....
Although the expression of the non-classical HLA class I molecule HLA-G was first reported to be restricted to the fetal–maternal interface on the extravillous cytotrophoblasts, the distribution of HLA-G in normal tissues appears broader than originally described. HLA-G expression was found in ...
Although the expression of the non-classical HLA class I molecule HLA-G was first reported to be restricted to the fetal–maternal interface on the extravillous cytotrophoblasts, the distribution of HLA-G in normal tissues appears broader than originally described. HLA-G expression was found in ...
CSCs interfere with immune cell activity directly or through cytokines. CSCs suppress or evade antitumorigenic T cells in part by immune checkpoint (MHC-I, PD-L1 and CD80). CSCs reduce DCs mature and differentation via TGFβ and Ev (MHC-I, HLA-G). NKG2DL are able to kill MHC-I negati...
Since it has been demonstrated that HLA-C and HLA-E are needed for protection from natural killer (NK) cell-mediated death [23], the up-regulation of HLA-C by Tat suggests similar host cell survival-directed functions for both Tat and Nef. Interestingly, HLA-G has been shown to be up...
4e). Furthermore, the expression of immune checkpoints and MHC molecules including CD274, CD44, CXCL10, and HLA-E/F/G were also up-regulated in tumors of squamous cell carcinoma (Fig. 4f). We thus speculate that squamous cell carcinoma has an active immune microenvironment and may be ...
S1a–d). The cells expressed CD146, CD105, and CD73, but not CD34, CD45, CD14, CD11b, and human leukocyte antigen (HLA)-class II antigen HLA-DR by flow cytometric analysis (Supplementary Fig. S1e). The cells were differentiated into osteoblasts, chondrocytes, and adipocytes (...
A bispecific antibody-IFNalpha2b immunocytokine targeting CD20 and HLA-DR is highly toxic to human lymphoma and multiple myeloma cells. Cancer Res , 2010 , 70(19): 7600 -9 Google Scholar [46] Szegezdi E, Leverkus M. Guiding the Killer and Bringing in Accomplices: Bispecific Antibody...
(ImmTACs) due to its MoA and engineering. The design involves the fusion of two proteins. The first protein arm contains a soluble high-affinity TCR that recognizes a complex formed by a specific peptide of the gp100 protein presented by HLA-A*02:01, which is expressed in approximately 45...
Fuggle NR, Cooper C, Oreffo ROC, Price AJ, Kaux JF, Maheu E, Cutolo M, Honvo G, Conaghan PG, Berenbaum F, Branco J, Brandi ML, Cortet B, Veronese N, Kurth AA, Matijevic R, Roth R, Pelletier JP, Martel-Pelletier J, Vlaskovska M, Thomas T, Lems WF, Al-Daghri N, Bruyère...