However, the surge in RCD research only started when the term “apoptosis” was coined in 1972 by John Kerr, Andrew Wyllie, and Alastair Currie1 (Fig. 1). Kerr et al. defined apoptosis as a form of programmed cell death (PCD) with morphological changes that differ from necrosis.1 ...
apoptosisprogrammedcelldeathneuroscienceThis brief essay offers a perspective concerning the etymon of the term "apoptosis," a term that is currently and widely recognized as a synonym for programmed cell death. The origin of the term from the Greek and a historical perspective of how the concept ...
In addition to activating the intrinsic apoptosis pathway, MOMP plays an important role in mitophagy, which is a broad term used to refer to the selective degradation of mitochondria in lysosomes via a specific autophagic pathway6. Mitophagy is an efficient way of clearing injured mitochondria to ...
Anamorsin (AM) (also called CIAPIN-1) is an anti–cell death factor that we originally identified in the Ba/F3 cell line. Ba/F3 cells are dependent on interleukin (IL) 3 stimulation [1], and we showed that AM conferred resistance to apoptosis induced by the lack of IL-3 stimulation....
apoptosis [30]. G6PD is a key rate-limiting enzyme in the pentose phosphate pathway (PPP), and how it participates in the regulation of the Warburg effect still needs further study [58]. It is worth noting that the G6PD-mediated PPP pathway is the main way to generate NADPH, which is ...
We noticed that B-LMO2 was related to “positive regulation of NF-κB signaling” and “T-cell receptor and B cell receptor signaling pathway”, and apoptosis is one of the characteristics of GC cells [34]. “Positive regulation of cell proliferation” “cell differentiation” and “positive ...
traditional biochemical markers of acute infection, such as C reactive protein (CRP), ferritin and erythrocyte sedimentation rate (ESR), as well as lymphopenia, probably due to T cell redistribution to the lungs, exhaustion, or depletion through TNF-α-mediated apoptosis (Figure 8) [58,59,60]...
The lower atrazine concentration (2 mg Kg−1) affected in the shortest term (7 days) the rate of cocoon production and increased LDH activity and, especially, the AChE activity in around 40%. The presence of a higher concentration (10 mg Kg−1) of the herbicide reduced one third of ...
apoptosis when compared with the well-differentiated adenomas, both of which rather occur later. Thus, the discrete step of dedifferentiation is not driven by observable alterations in the hallmark traits of sustained proliferation and resistance to apoptosis. Rather, upregulation of a miRNA previously...
Apoptosis was long considered the principal form of cell death in various cancer types; however, apoptosis-based cancer therapies have limited clinical benefit.33Therefore, identifying novel cancer therapeutics that target pathways other than apoptosis is now an urgent unmet clinical need. Indeed, the ...