However, the surge in RCD research only started when the term “apoptosis” was coined in 1972 by John Kerr, Andrew Wyllie, and Alastair Currie1 (Fig. 1). Kerr et al. defined apoptosis as a form of programmed cell death (PCD) with morphological changes that differ from necrosis.1 ...
Apoptosis was long considered the principal form of cell death in various cancer types; however, apoptosis-based cancer therapies have limited clinical benefit.33Therefore, identifying novel cancer therapeutics that target pathways other than apoptosis is now an urgent unmet clinical need. Indeed, the ...
TBS in conjunction with BMD, is useful for monitoring individual response to long-term denosumab treatment (5 years or more). 10. TBS in conjunction with BMD is useful for monitoring individual response to PTH/PTHrP-analogue treatments such as teriparatide and abaloparatide. 11. TBS in conju...
The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital ma
Other events in apoptosis are the complex cascade of caspases. It was reported that Annomuricin E caused depletion of mitochondrial membrane potential (MMP) leading to opening of mitochondrial permeability transition pores and further release of pro-apoptotic proteins, such as cytochrome c from the ...
The term “prolonged” identifies a period of continuous statin intake of more than 6 months. This period was assessed by observing data extrapolated from the selected articles, in which the shortest time of statin treatment before symptoms was around 8 months. The definition of 6 months as "...
The apoptosis-associated Speck-like protein containing a caspase-1 recruitment domain (ASC), present in inflammasomes, regulates inflammation events and is involved in osteogenic phenotype. Nevertheless, its function in bone repair induced by bone substitute biomaterials is unclear. This study aimed to ...
,... - APOPTOSIS -OXFORD- 被引量: 78发表: 2008年 High carbohydrate and high fat diets protect the heart against ischaemia/reperfusion injury myocardial ischaemia/reperfusion damage in two models of diet-induced obesity as well as the effect of ischaemic and pharmacological preconditioning on such ...
This study introduces the term ferroptosis to describe a novel form of non-apoptotic cell death and identifies the small molecule ferrostatin 1 as the first specific inhibitor of ferroptosis. Article CAS Google Scholar Ganz, T. Systemic iron homeostasis. Physiol. Rev. 93, 1721–1741 (2013). ...
Apoptosis is the most classic form of cell death. A transcriptomic study using deep RNA sequencing identified differentially expressed circRNAs in HeLa cells under apoptotic conditions and manifested the potential regulatory role of circRNAs in apoptosis [211]. A well-studied circRNA derived from the ...