In 1972, Kerr coined the term of apoptosis (programmed cellular death) to indicate that this way of cellular death was related to organic damage; but in contrast to other ways of death characterized by active cellular necrosis, in this, there is very little tissular reaction surrounding ...
Although the term “ferroptosis” was first coined by Dixon et al. in 2012 (Fig.1a), a similar form of neuronal cell death triggered by cysteine depletion called “oxytosis” was reported by Murphy et al. back in 1989;8this neuronal cell death was induced by the excitotoxin glutamate b...
The term “nonmotile ciliopathy” refers to diseases that tend only to affect the function of nonmotile, primary cilia, and not the motile cilia, familiarly lining epithelia and powering sperm movement. Many disease gene products localize to the basal bodies and centrosomes too, but here we on...
n. The apoptosis assay was conducted using an Annexin V-APC/PI Apoptosis Kit in Ty82 cells treated with Rosiglitazone or the control group. o-p. Western blot analysis was performed to assess the protein expression levels of EMT markers, including N-cadherin, E-cadherin, and Vimentin, in ...
The feasibility of mRNA electroporation for CAR engineering of short-term activation NK cells has been demonstrated. CAR-NK cells delivered via mRNA retain their sensitivity to innate signals and exhibit varying cytotoxicity profiles dictated by their subsets [204]. mRNA transfection through ...
The primary purpose of viral vectors was initially to address the challenge of delivering DNA, and many researchers have utilized them for this purpose in the treatment of genetic disorders [116]. The earliest successful treatment case was observed in a long-term clinical trial under the guidance...
These genes typically respond to various signals that drive cell proliferation, growth, apoptosis, metabolism, cell-size control, genome integrity, and differentiation. While members of the Myc family share a significant degree of homology, they exhibit slightly different expression patterns. MYCN is a...
This study is part of a long-term and comprehensive research involving various biological activities of extracts of plants from the Lamiaceae family. The main objective of this study was to assess the ability of methanolic, ethanolic, and aqueous extracts of six Lamiaceae species in preserving the...
The Writing Committee considered evidence published since 2001 and drafted revised recommendations to incorporate results from major clinical trials such as those that compared rhythm control and rate control approaches to long-term management. The text has been reorganized to reflect the implications for...
Impaired social behavior [112] Short-term recognition memory defects [119] Neuronal morphology alterations Neuronal differentiation delaya Accelerated neuronal differentiation Decreased axonal length [88], [112] Increased axonal length [27], [106] Increased dendritic arborization [112] Increased axonal bra...