2000 . The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain . EMBO J. 19 : 5587 – 5598 .Liker, E. , Fernandez, E. , Izaurralde, E. & Conti, E. ( 2000 ) The structure of the mRNA export factor TAP reveals a...
In bacteria, translation of all the ribosomal protein cistrons in the spc operon mRNA is repressed by the binding of the product of one of them, S8, to an internal sequence at the 5' end of the L5 cistron. The way in which the first two genes of the spc operon are regulated, retro...
Strikingly, no electron density could be observed for the QUA2 region of T-STAR in all our data sets, suggesting that the QUA2 region does not adopt a well-defined orientation. Accordingly, the structure of T-STAR STAR in complex with AUUAAA overlay very well with the structure of T-STAR...
FGF-18 mRNA of approximately 2. 7 kilobases was preferentially detected in the lung among adult rat tissues examined. In rat embryos, FGF-18 mRNA was detected in several discrete regions at embryonic days 14.5 and 19.5 but not at E10.5. The temporal and spatial patterns of FGF-18 mRNA ...
The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation. Nucleic Acids Res. 2015;43:3826–40. CAS PubMed PubMed Central Google Scholar Xie JJ, Jiang YY, Jiang Y, Li CQ, Lim MC, An O, et al. Super-enhancer-driven long...
Describe the structure of RNA. RNA types: mRNA, rRNA, tRNA. How does each type of RNA function? How are DNA and RNA molecules similar and different in their structure and functions? When comparing the polarity of mRNA to the primary amino acid sequence, it can be said that ___...
The Ccr4-Not complex is involved in several aspects of gene expression, including mRNA decay, translational repression and transcription. We determined the 2.8-angstrom-resolution crystal structure of a 120-kDa core complex of the Saccharomyces cerevisiae Not module comprising the C-terminal arm of No...
In this paper we investigate and compare (evolutionary) patterns in the primary and secondary structure of four homologous E1a mRNAs of the adenovirus. Our main results are as follows: (1) The similarity of the coding regions of the mRNA sequences reflects both similarity in function (i.e.,...
1 RNA structure The Structure of tRNA. The role of tRNA is two fold, bind to and accept the correct amino acid from the appropriate tRNA synthetase and recognize and bind the ribosome-mRNA complex to deliver the amino acid to the growing polypeptide chain. Because of its central role in ge...
(mRNA) export and a hotspot for nucleoporin-associated diseases, has remained elusive. Here we report a composite structure of the human cytoplasmic face obtained by combining biochemical reconstitution, crystal structure determination, docking into cryo–electron tomographic reconstructions, and ...