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The gut microbiota is implicated in the etiology of nonalcoholic fatty liver disease (NAFLD) as well as progression to the more severe nonalcoholic steatohepatitis. Evidence supporting this role is mainly from animal models, although data from human stud
The role of the gut microbiota in NAFLD Nature Reviews Gastroenterology & Hepatology, 13 (7) (2016), pp. 412-425, 10.1038/nrgastro.2016.85 View in ScopusGoogle Scholar Li et al., 2014 M. Li, A. Shi, H. Pang, W. Xue, Y. Li, G. Cao, B. Yan, F. Dong, K. Li, W. Xiao,...
Moreover, there exists an interaction between the gut microbiota and exosomes. We discuss whether this interaction plays a role in the pathogenesis of ALD and whether it can be a potential therapeutic target for ALD treatment. Key scientific concepts of review Chronic alcohol intake alters the ...
A study using a transplantation mouse model demonstrated the role of the gut microbiota in NAFLD development. Mice fed a high-fat diet developed hepatic macrovesicular steatosis after colonization with microbiota from hyperglycemic mice, while the control mice that were treated with microbiota from ...
In this review, the current evidence regarding the key role of the gut microbiota and its metabolites in the pathogenesis and development of NAFLD is highlighted, and the advances in the progression and applied prospects of gut microbiota-targeted dietary and exercise therapies is also discussed....
and cognition has consequently subsidized to establish the microbiota–gut–brain axis as an extension of the well-accepted gut–brain axis concept. Numerous exertions have been focused on demarcating a role for this axis in health and disease, ranging from stress-associated conditions such as depr...
Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity. Cell Rep Med. 2023;4(12):101341. Article PubMed PubMed Central Google Scholar Lai J, Luo L, Zhou T, Feng X, Ye J, Zhong B. Alterations in circulating bile acids in ...
Role of the gut microbiota in NAFLD Given that the liver is directly linked to the intestine via the portal blood and that the gut microbiome is a major source of acetate, it is not surprising that the gut microbiome plays important roles in NAFLD. Sequencing studies indicated specific changes...
et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482, 179–185 (2012). Article CAS PubMed PubMed Central Google Scholar Zhu, Q., Gao, R., Wu, W. & Qin, H. The role of gut microbiota in the pathogenesis of colorectal cancer. Tumour Biol. 34,...