The gut microbiota is involved in gut permeability, low-grade inflammation and immune balance, it modulates dietary choline metabolism, regulates bile acid metabolism and produces endogenous ethanol. All of these factors are molecular mechanisms by which the microbiota can induce NAFLD or its ...
In this review, the current evidence regarding the key role of the gut microbiota and its metabolites in the pathogenesis and development of NAFLD is highlighted, and the advances in the progression and applied prospects of gut microbiota-targeted dietary and exercise therapies is also discussed....
The gut microbiota has been shown to play a role in the pathogenesis of liver diseases such as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), and liver cirrhosis. NAFLD is a condition in which fat accumulates in the liver, leading to inflammation and damage to ...
Gut microbiotaNon-alcoholic fatty liver diseaseGerm-free animalsDysbiosisMetabolic syndromeBile acidsIntestinal permeabilityAntibioticsProbioticsPrebioticsNAFLD is currently the main cause of chronic liver disease in developed countries, and the number of NAFLD patients is growing worldwide. NAFLD often has ...
Table 1 Studies suggesting a causal relationship between the gut microbiota and NAFLD. Full size table The role of microbiota-derived short-chain fatty acids (SCFAs) in NAFLD How do fructose-mediated microbial population shifts affect the onset of NAFLD? One clinical study found a link between hi...
Evidence is accumulating that the gut microbiome is involved in the aetiology of obesity and obesity-related complications such as nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes mellitus (T2DM). The gut microbiota is able to ferment indigestible carbohydrates (for ex...
III. NASH/NAFLD and Gut Microbiota The gut microbiota plays a key role in the development of chronic inflammatory liver disease. The gut-liver axis involves inflammatory cells, cytokines, and other molecules that cause liver deterioration. Dysbiosis is important in unders... K Tomita,R Hokari -...
The findings hint at the potential of using gut microbiota for early clinical warning of non-invasive NAFLD and open a window of opportunities for novel microbiome-based interventions for NAFLD treatment, the researchers said.■
Non-alcoholic fatty liver disease (NAFLD) has recently been considered to be under the influence of the gut microbiota, which might exert toxic effects on the human host after intestinal absorption and delivery to the liver via the portal vein. In this study, the composition of the gut ...
The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD Abstract Maternal obesity is associated with increased risk for offspring obesity and non-alcoholic fatty liver disease (NAFLD), but the causal drivers of this association are unclear. Early colonization of...