Human studies have started to describe microbiota alterations in NAFLD and have found a few consistent microbiome signatures discriminating healthy individuals from those with NAFLD, non-alcoholic steatohepatiti
In this review, the current evidence regarding the key role of the gut microbiota and its metabolites in the pathogenesis and development of NAFLD is highlighted, and the advances in the progression and applied prospects of gut microbiota-targeted dietary and exercise therapies is also discussed....
Non-alcoholic fatty liver disease (NAFLD) has recently been considered to be under the influence of the gut microbiota, which might exert toxic effects on the human host after intestinal absorption and delivery to the liver via the portal vein. In this study, the composition of the gut ...
Drugs, especially antibiotics, also affect the homeostasis of probiotics and the integrity and function of the intestinal mucosa. These interplaying processes produce a variety of important metabolites of the host and drugs and affect the balance of microbiota and the mucosal barrier then modulate the...
The gut microbiota has been shown to play a role in the pathogenesis of liver diseases such as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), and liver cirrhosis. NAFLD is a condition in which fat accumulates in the liver, leading to inflammation and damage to ...
3. Liu Q, et al. Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome. Gut. 2022; 71(3): 544-552. 4. Andersson, D.I., Nicoloff, H. & Hjort, K. Mechanisms and clinical relevance of bacterial heteroresistance. Nat Rev Microbiol. 2019; 17, ...
Research has shown that alterations in the gut microbiota composition and function can contribute to the pathogenesis of various liver conditions, such as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), and liver cirrhosis. For example, an overgrowth of harmful bacteria or...
Finally, we found that FA did not have hepatorenal toxicity. The findings above illustrate that FA has the potential to ameliorate NAFLD, some of which are closely related to the modulation of specific gut microbiota and the regulation of genes involved in TG and TC metabolism....
The findings hint at the potential of using gut microbiota for early clinical warning of non-invasive NAFLD and open a window of opportunities for novel microbiome-based interventions for NAFLD treatment, the researchers said.■
We aimed to evaluate the association between gut dysbiosis and severe NAFLD lesions, i.e. non-alcoholic steatohepatitis (NASH) and fibrosis, in a well-characterized population of adult NAFLD.57 patients with biopsy-proven NAFLD were enrolled. The taxonomic composition of gut microbiota was ...