Human studies have started to describe microbiota alterations in NAFLD and have found a few consistent microbiome signatures discriminating healthy individuals from those with NAFLD, non-alcoholic steatohepatitis or cirrhosis. However, patients with NAFLD often present with obesity and/or insulin resistance...
The gut microbiota is involved in gut permeability, low-grade inflammation and immune balance, it modulates dietary choline metabolism, regulates bile acid metabolism and produces endogenous ethanol. All of these factors are molecular mechanisms by which the microbiota can induce NAFLD or its ...
In this review, the current evidence regarding the key role of the gut microbiota and its metabolites in the pathogenesis and development of NAFLD is highlighted, and the advances in the progression and applied prospects of gut microbiota-targeted dietary and exercise therapies is also discussed....
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We aimed to evaluate the association between gut dysbiosis and severe NAFLD lesions, i.e. non-alcoholic steatohepatitis (NASH) and fibrosis, in a well-characterized population of adult NAFLD.57 patients with biopsy-proven NAFLD were enrolled. The taxonomic composition of gut microbiota was ...
The gut microbiota has been shown to play a role in the pathogenesis of liver diseases such as non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), and liver cirrhosis. NAFLD is a condition in which fat accumulates in the liver, leading to inflammation and damage to ...
Gut microbiotaNon-alcoholic fatty liver diseaseGerm-free animalsDysbiosisMetabolic syndromeBile acidsIntestinal permeabilityAntibioticsProbioticsPrebioticsNAFLD is currently the main cause of chronic liver disease in developed countries, and the number of NAFLD patients is growing worldwide. NAFLD often has ...
The findings hint at the potential of using gut microbiota for early clinical warning of non-invasive NAFLD and open a window of opportunities for novel microbiome-based interventions for NAFLD treatment, the researchers said.■
NASH是脂肪变性结合炎症(liver inflammation)和/或纤维化(fibrosis)而形成的NAFLD高级表现。NASH进一步发展可引起更为严重的肝硬化(liver cirrhosis)和肝癌(hepatocellular carcinoma)。 肠道菌群(gut microbiota)可以分泌多种酶催化宿主体内的反应,如初级胆汁酸只能在肠道菌群分泌的胆酸水解酶(bile salt hydrolase, BSH)、...
Non-alcoholic fatty liver disease (NAFLD) has recently been considered to be under the influence of the gut microbiota, which might exert toxic effects on the human host after intestinal absorption and delivery to the liver via the portal vein. In this study, the composition of the gut ...