Ferroptosis is a regulated form of necrotic cell death reliant on iron-catalyzed lipid peroxidation. Although the precise involvement of mitochondria in ferroptosis remains incompletely elucidated, recent research indicates that mitochondrial oxidative events wield a pivotal influence in this mechanism. This ...
12,13,14]. Paradoxically, mitochondria play a central role in apoptotic cell death [15], pyroptosis [16], necroptosis [17], ferroptosis [4], and other forms of cell death. The classical mitochondrial pathway in apoptosis is related
Ferroptosis, a form of regulated cell death caused by lipid peroxidation, was recently identified as a natural tumor suppression mechanism. Here, we show that ionizing radiation (IR) induces ferroptosis in cancer cells. Mechanistically, IR induces not on
Ferroptosis is a form of regulated necrosis associated with the iron-dependent accumulation of lipid hydroperoxides that may play a key role in the pathogenesis of degenerative diseases in which lipid peroxidation has been implicated. High-throughput screening efforts have identified ferrostatin-1 (Fer-...
(2022) 22:266 https://doi.org/10.1186/s12935-022-02685-w Cancer Cell International REVIEW Open Access The role of ferroptosis in esophageal cancer Zimin Wang1,2†, Sikai Wu1,2†, Chengchu Zhu1,2* and Jianfei Shen1,2* Abstract Esophageal cancer is one of the...
in AD. However, the underlying mechanisms have not been fully elucidated. This article reviews the potential role of ferroptosis in AD, the involvement of ferroptosis in the pathological progression of AD through the mechanisms of iron metabolism, lipid metabolism, and redox homeostasis, as well as...
The discovery of regulated cell death processes has enabled advances in cancer treatment. In the past decade, ferroptosis, an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, has been implicated in the development and therapeutic responses of various types of tumours...
Radiotherapy is one of the main therapies for cancer. The process leading to radioresistance is still not fully understood. Cancer radiosensitivity is rela
DFO is an iron chelator, while ferrostatin-1 and Lip-1 prevent the accumulation of lipid peroxides [21], [22]. To explore whether ferroptosis participates in the antimalarial mechanisms of DHA and to assess the role of ferroptosis in the parasite killing of DHA,we selected DHA, ERA, RSL3,...
Multiple oxidative and antioxidant systems, acting together with the autophagy and membrane repair machinery, shape the process of lipid peroxidation during ferroptosis. In tumorigenesis, ferroptosis has a dual role in tumour promotion and suppression, which depends on the release of damage-associated mo...