In terms of mechanism, it improves vascular endothelial dysfunction and phenotypic transformation of vascular smooth muscle cells. All the above evidence suggests that irisin plays a predictive and protective role in vascular calcification. In this review, we summarize the association o...
The well-described physiological functions of irisin include its role in the browning of white adipose tissue, the regulation of insulin metabolism, and its anti-inflammatory and antioxidative effects [21]. Recombinant irisin injection or the endogenous release of irisin by exercise has been reported ...
Relatively high FNDC5 mRNA expression during the prepubertal period will indicate a potential inhibitory role of irisin on puberty onset. However, if FNDC5 mRNA Conclusions In summary, we proposed the hypothesis that irisin, a protein product of the FNDC5 gene, serves as a metabolic trigger for...
Functional studies of irisin demonstrated that its metabolic role was to mediate exercise-related energy expenditure by turning white adipose tissue (WAT) into brown adipose tissue (BAT) in response to activation of the peroxisome proliferator-activated receptor-gamma coactivator-1 α (PGC-1α) [133...
Role of Irisin in exercise training-regulated endoplasmic reticulum stress, autophagy and myogenesis in the skeletal muscle after myocardial infarction However, the precise role of Irisin in the benefits of ET on inhibiting skeletal muscle atrophy, particularly on endoplasmic reticulum (ER) stress, .....
Abnormalities of the pyroptosis signaling cascade have been observed in the pathogenesis of degenerative diseases of the elderly. This review summarizes the molecular mechanisms and signaling pathways of pyroptosis, and explores the central role of pyroptosis in degenerative diseases such as presbycusis, ...
on the one hand, on the other hand, it is benefit for anticancer activities. In this review, we will summarize the current discovery on the role and impact of TRPV4 in these programmed cell death pathological mechanisms to provide a new prospect of gene therapeutic target of related diseases...
Pyroptosis is a controlled form of inflammatory cell death characterized by inflammasome activation, pore formation, and cell lysis. According to different caspases, pyroptosis can be divided into canonical, non-canonical, and other pathways. The role of
We also summarize preclinical experiments on crosstalk-based and the current state of clinical studies on VC-related measures.Similar content being viewed by others A novel role of cellular interactions in vascular calcification Article Open access 03 May 2017 Vascular pathologies in chronic kidney ...
At present, the key regulators and complicated network mechanisms associated with ferroptosis have been deeply studied; however, its role in the initiation and progression of kidney diseases has not been fully revealed. Herein, we aim to discuss the features, key regulators and complicated network ...