In this Review, we present the current knowledge on the physiology of irisin and its role in glucose homeostasis. We describe the mechanisms involved in the synthesis, secretion, circulation and regulation of irisin, and the controversies regarding the measurement of irisin. We also discuss the ...
Role of irisin in physiology and pathology Front. Endocrinol., 13 (2022), Article 962968, 10.3389/fendo.2022.962968 View in ScopusGoogle Scholar [8] M.P. Jedrychowski, C.D. Wrann, J.A. Paulo, K.K. Gerber, J. Szpyt, M.M. Robinson, K.S. Nair, S.P. Gygi, B.M. Spiegelman Det...
Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the central nervous system (CNS). The underlying pathophysiology of MS is the destruction of myelin sheath by immune cells. The formation of myelin plaques, inflammati
agonists such as fenofibrate, gemfibrozil and ciprofibrate could attenuate the inflammatory reactions in MS. It has been reported that gemfibrozil attenuates experimental autoimmune encephalomyelitis (EAE), an animal model of relapsing–remitting multiple sclerosis (RMS) in mice by inhibiting encephalitogen...
Regulation of energy balance by inflammation: common theme in physiology and pathology. Rev. Endocr. Metab. Disord. 16, 47–54 (2015). Article CAS PubMed PubMed Central Google Scholar van den Berg, S. M., van Dam, A. D., Rensen, P. C., de Winther, M. P. & Lutgens, E. ...
The rise of irisin in the luteal phase suggests that it might be involved in the ovulation cycle. Furthermore, serum irisin levels were found to rise during normal pregnancy. Additionally, irisin levels are higher in middle and late pregnancy with respect to early pregnancy in healthy women, ...
However, whether irisin prote... H Wang,YT Zhao,S Zhang,... - 《Journal of Cellular Physiology》 被引量: 8发表: 2017年 AMindofItsOwn:ACulturalHistoryofthePenis(review) Then Leonardo plays a pivotal role in a new shift to secular appreciation and investigation, resulting first in the ...
Administration of irisin promotes myocardial functions and could be translated into clinical settings after preclinical profiling. Keywords: irisin; myocytes; gene expression; heart physiology 1. Introduction Physical exercise is correlated with hemodynamic changes and alters the loading conditions of the ...
In this review, we explain the potential role of these exercise-inducible factors, namely myokines, such as irisin, IL-6, IL-15, METRNL, BAIBA, and myostatin, and hepatokines, in particular selenoprotein P, fetuin A, FGF21, ANGPTL4, and follistatin. We also describe the function of ...
Physiology and role of irisin in glucose homeostasis. Nat. Rev. Endocrinol. 2017, 13, 324–337. [Google Scholar] [CrossRef] [PubMed] [Green Version] So, W.Y.; Leung, P.S. Irisin ameliorates hepatic glucose/lipid metabolism and enhances cell survival in insulin-resistant human HepG2 ...