The principles of directed cell migration Article 14 May 2021 Introduction Cell migration plays important roles in many cellular processes, such as morphogenesis, immune responses, and wound healing. The cytoskeleton has been well established to contribute to cell migration. Cells migrate by extending ...
NADPH oxidase 1 controls the persistence of directed cell migration by a Rho-dependent switch of α2/α3 integrins. Mol. Cell Biol. 29, 3915–3928 (2009). Article CAS PubMed PubMed Central Google Scholar Park, M. T. et al. Novel signaling axis for ROS generation during K-Ras-induced...
In contrast, cell migration is dysregulated in many pathological situations, such as cancer metastasis and inflammation. Not surprisingly, the principles behind cell migration have been studied in many contexts. Wound healing assays and migration assays are widely used approaches for the analysis of ...
First, gene module D was enriched for pro-regenerative processes related to angiogenesis, EMT and wound repair, including blood vessel development, circulatory system development, angiogenesis, cell migration and extracellular matrix organization (Fig. 3f and Supplementary Table 6). Commitment of ...
Development of the posterior lateral line (PLL) system in zebrafish involves cell migration, proliferation and differentiation of mechanosensory cells. The PLL forms when cranial placodal cells delaminate and become a coherent, migratory primordium that traverses the length of the fish to form this se...
Its involvement in cancer biology has been already described so much that it can be accounted as a prognostic biomarker of different tumors [24, 25]. P4HA1 enzymatic activity was described in relation to cell proliferation, invasion, migration and metastasis development processes in different tumors...
First-principles calculations based on density functional theory (DFT) within the generalized gradient approximation (GGA) have been carried out to study the migration of helium in tungsten. The results show that helium interstitial jump directly between two tetrahedral sites with very low migration ...
organizational and methodological principles have been developed by the SoBigData Project, in order to establish a Responsible Research Infrastructure, allowing users to make full use of the functionalities and capabilities that big data can offer to help us solve our problems, while at the same tim...
Cell-based therapeutics are an emerging modality with the potential to treat many currently intractable diseases through uniquely powerful modes of action. Despite notable recent clinical and commercial successes, cell-based therapies continue to face numerous challenges that limit their widespread translation...
These mechanisms are based both on direct physical interactions, which coordinate the cellular responses, and on the collective cell behaviour that generates an optimal environment for efficient directed migration. The recent studies have described how leader cells at the front of cell groups drive ...