Positive regulation of cell migration and invasion by VASP via Rac1 pathway in human mammary epithelial cellsObjective: To study the role of cytoskeleton associated protein vasodilator-stimulated phosphoprotein (VASP) on migration of human mammary epithelial tumor cells and its mechanism. Methods: The ...
Temporal inhibition of mouse mammary gland cancer metastasis by CORM-A1 and DETA/NO combination therapy Moreover, we analyzed the compounds' direct effect on 4T1 mouse and MDA-MB-231 human breast cancer cells proliferation, adhesion and migration in vitro. Results: We have observed antimetastatic ...
Sphingosine-1-phosphate (S1P) exerts positive and negative effects on cell migration apparently in a cell-type-dependent manner. Our data suggest that the bimodal actions of S1P on cell migration is due to receptor subtype-specific positive and negative regulation of Rho family GTPase, Rac; S1P ...
Importantly, we demonstrate in vivo relevance for both kinases in the regulation of basal mitophagy. Knockdown of GAK homologue (gakh-1) in C. elegans or knockout of PRKCD homologues in zebrafish led to significant inhibition of basal mitophagy, highlighting the evolutionary relevance of these ...
microRNA-3129 promotes cell proliferation in gastric cancer cell line SGC7901 via positive regulation of pRb. microRNA-3129 promotes cell proliferation in gastric cancer cell line SGC7901 via positive regulation of pRb:doi:10.1590/1414-431x20186452.microRNA-3129... YANG,Shaofeng - 《Brazilian ...
Positive feedback regulation of lncRNA PVT1 and HIF2α contributes to clear cell renal cell carcinoma tumorigenesis and metastasisMing-xiao Zhang, Li-zhen Zhang, Liang-min Fu, Hao-hua Yao, Lei Tan, Zi-hao Feng, Jia-ying Li, Jun Lu, Yi-hui Pan, Guan-nan Shu, Peng-ju...
Selection events on coding sequences may also have effects on gene expression regulation. One transcription factor that showed signs of positive selection along the human lineage was HIVEP3(immunodeficiency virus type I enhancer binding protein 3). This gene belongs to a family of zinc-finger protei...
Mechanism of regulation of transcription initiation by ppGpp. II. Models for positive control based on properties of RNAP mutants and competition for RNAP 1 Strains containing ppGpp, a nucleotide whose synthesis is dependent on the RelA and SpoT proteins of Escherichia coli, display slightly lower...
Phototropins are light-activated protein kinases, which contribute to photosynthesis optimization both through enhancement of photon absorption when light is limiting and avoidance responses in high light. This duality is in part endowed by the presence
The enteric neurotransmitter acetylcholine governs important intestinal epithelial secretory and immune functions through its actions on epithelial muscarinic Gq-coupled receptors such as M3R. Its role in the regulation of intestinal stem cell function a