Osteoarthritis (OA) is a progressive joint disease that worsens with age. It is the most common form of arthritis and a serious clinical concern in an aging population. Several risk factors associated with OA pathophysiology, including trauma-, age-, genetics- and obesity-related triggers, cause...
This article summarizes the current understanding of the pathophysiology of knee osteoarthritis (OA). OA is a common disease of diarthrodial joints with marked prevalence in aging individuals. It is a complex, heterogeneous, whole-joint disease with multiple etiologies. Although articular cartilage dege...
Research into the pathophysiology of osteoarthritis (OA) has focused on cartilage and peri-articular bone, but there is increasing recognition that OA affe... CR Scanzello,SR Goldring - 《Bone》 被引量: 746发表: 2012年 The role of bone in osteoarthritis OsteoarthritisPathophysiologySubchondral bone...
We elucidated the molecular cross-talk between cartilage and synovium in osteoarthritis, the most widespread arthritis in the world, using the powerful tool of single-cell RNA-sequencing. Multiple cell types were identified based on profiling of 10,640 synoviocytes and 26,192 chondrocytes: 12 distinc...
The positive effects of chondroitin sulfate on the pathophysiology of osteoarthritis are possibly due to its contribution to a proper balance between anabolism/catabolism in the articular tissues.Previous article in issue Next article in issue
Recent pharmacological developments allow the clinician not only to control clinical signs of the disease, but also to slow the progression of cartilage degeneration. 展开 关键词: Canine Degenerative Joint Disease Management Osteoarthritis Pathophysiology ...
Osteoarthritis of the trapeziometacarpal joint: The pathophysiology of articular cartilage degeneration. I. Anatomy and pathology of the aging joint 来自 Semantic Scholar 喜欢 0 阅读量: 59 作者:Pellegrini,D Vincent 摘要: An anatomic study of the trapeziometacarpal joint was conducted on 47 cadaver ...
Treatments for osteoarthritis (OA) are designed to restore chondrocyte function and inhibit cell apoptosis. Previous studies have shown that activation of the glucagon-like peptide-1 receptor (GLP-1R) leads to anti-inflammatory and anti-apoptotic effects. However, the role of GLP-1R in the patholo...
Osteoarthritis (OA), one of the most common rheumatic disorders, is characterized by cartilage breakdown and by synovial inflammation that is directly linked to clinical symptoms such as joint swelling, synovitis and inflammatory pain. The gold-standard method for detecting synovitis is histological anal...
The membranous receptor syndecan-4 (SDC-4) and the nuclear transcription factor hypoxia-induced factor-2α (HIF-2α) play critical roles in the pathogenesis of osteoarthritis (OA). The aim of this study was to determine whether SDC-4 inhibition downregul