Osteoarthritis (OA), a whole-joint disease driven by abnormal biomechanics and attendant cell-derived and tissue-derived factors, is a rheumatic disease with the highest prevalence, representing a severe health burden with a tremendous economic impact. Members of the nuclear factor κB (NF-κB) ...
Pathophysiology of osteoarthritis The specific causative agent of the pathological process of osteoarthritis (OA) has not yet been identified, however, episodic inflammation at the clinical... J Martel-Pelletier - 《Osteoarthritis & Cartilage》 被引量: 1084发表: 1999年 The pathophysiology of osteoarthri...
Objectives: Whether changes in the hyaluronan moiety of synovial fluid are associated with osteoarthritis (OA) is unresolved experimentally, notwithstanding frequent statements in the literature that the disease leads to degraded hyaluronan. We evaluated this hypothesis by comparing the molecular weight and...
Osteoarthritis is traditionally thought of as a ‘wear and tear’ disease which occurs as we age. However, recent research suggests otherwise.The pathogenesis of OA involves a degradation of cartilage and remodelling of bone due to an active response of chondrocytes in the articular cartilage and ...
Osteoarthritis (OA) is one of the most common chronic diseases, with increasing importance due to increased life expectancy. On a cellular level, the pathophysiology of joint function impairment and ultimate destruction associated with OA remains poorly understood. Free radicals are highly reactive molec...
2003Sinkov V,CymetT.Osteoarthritis:understanding the ... V Sinkov,T Cymet - 《Journal of the National Medical Association》 被引量: 97发表: 2003年 Extracellular vesicles in the pathogenesis of rheumatoid arthritis and osteoarthritis Osteoarthritis (OA) and rheumatoid arthritis (RA) are both ...
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling and inflammation of the synovial membrane, although the etiology ... Kapoor,Mohit,Martel-Pelletier,... - 《Nature Reviews Rheumatology》 被...
Osteoarthritis (OA) is a common condition affecting nearly 600 million people across the globe, with a significant burden of disability, especially in the ... O O'Sullivan - Palgrave Macmillan, Cham 被引量: 0发表: 2024年 Osteoarthritis: Pathophysiology, Prevalence, Risk Factors, and Exercise for...
The medical treatment of osteoarthritis (OA) in the horse is one of the most utilized therapeutic regimens in the equine practice. It is important to under... LR Goodrich,AJ Nixon - 《Veterinary Journal》 被引量: 325发表: 2006年 THE HORSE ' S BIT : A Bronze Age anachronism and cause ...
Association of APOE-ε4, Osteoarthritis, β-Amyloid, and Tau Accumulation in Primary Motor and Somatosensory regions in Alzheimer Disease. Neurology. 2023;101:e40–9. https://doi.org/10.1212/WNL.0000000000207369. Article CAS PubMed Google Scholar Guo T, Korman D, La Joie R, Shaw LM, ...