Given the widely held view that conditioned fear models the essential aspects of anxiety disorders, the results confirm the ERK/MAPK signaling pathway as a molecular target for the treatment of anxiety disorders in the clinic. Neuropsychopharmacology (2009) 34, 356–366; doi:10.1038/npp.2008.57; ...
The following primary antibodies were used: mouse monoclonal antibodies against myelin basic protein (MBP) (MAB382, 1:100; Chemicon, Temecula, CA), synaptophysin (MAB368, 1:500; Chemicon); rabbit polyclonal antibody against myelin protein zero (P0; a gift from Maria T. Filbin, City Universit...
Neuromed, Pozzilli (IS), Italy, 3Department of Chemistry, Universita` degli Studi di Milano, Milan, Italy, 4Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy. The role of microtubule (MT) dysfunction in Parkinson's disease is emerging. It is still unknown whether it ...
A 10-year, retrospective review of 3224 carotid endarterectomies performed at The Mayo Clinic revealed that 44 (1.4%) patients required wound exploration within 72 hours of surgery, despite the nonreversal of heparin.191 In two patients, re-exploration occurred before the initial extubation. The...
Immunohistochemical (IHC) analysis of human pancreatic cancer tissue arrays (PA483a, T143; US Biomax, Rockville, MD, USA) was conducted using monospecific antibodies against MMP-2 (MAB13405; EMD Millipore, Temecula, CA, USA) and TIMP-1 (E3360; Spring Biosciences, Pleasanton, CA, USA) as...
(seeMethodsand Additional file2: Figure S1). The Rax::EGFP rESCs were induced to retinal lineage differentiation by the same SFEBq method as used for rESC-RPC2 generation. Rax-driven expression of EGFP could be detected in some cells in the neuroectoderm-like structure at day 8, indicating...
(Carpinteria, CA, USA), goat polyclonal anti-BiP (1:50) and rabbit polyclonal anti-Fas (1:200) (Santa Cruz Biotechnology, Santa Cruz, CA, USA), rabbit polyclonal anti-3-nitrotyrosine (1:500) (Chemicon, Temecula, CA, USA), which were diluted in blocking solution and incubated over...
We sincerely thank the Lammert and Corkins family for their generous donation to the McMaster University Neuromuscular and Neurometabolic Centre. We greatly appreciate Jose Santana for his help with subject testing and supervision of exercise sessions. IAS was supported by the Heart and Stroke ...
A novel mitofusin 2 mutation causes canine fetal-onset neuroaxonal dystrophy. Neurogenet 2011; 12: 223–232. 26 Mignot E. Genetic and familial aspects of narcolepsy. Neurology 1998; 50 (2 Suppl 1): S16–S22. 27 Dowling AL, Head E. Antioxidants in the canine model of human aging. ...
John A. McDonald (Mayo Clinic, Scottsdale, AZ). Rabbit anti-laminin antibody was purchased from Chemicon (Temecula, CA). Rabbit anti-entactin antibody was kindly provided by Dr. Albert Chung (University of Pittsburgh). Monoclonal anti-paxillin antibody and horseradish peroxidase (HRP)- conjugated...