Transmission electron microscopy showed that the mitochondrial cristae were flattened in both lines, but the matrix of mitochondria in the cured line was more electron-transparent. Interestingly, in Alzheimer's disease patients, where mitochondrial dysfunction has an early and preponderant role in the...
Mic10, a core subunit of the mitochondrial contact site and cristae organizing system, interacts with the dimeric F1Fo-ATP synthase. J Mol Biol 429(8... Rampelt,Heike,Bohnert,... 被引量: 0发表: 0年 Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase Crosstalk...
2. Mitochondrial Dysfunction 2.1. General Aspects The mitochondria is a small organelle composed of two phospholipid bilayer membranes, a highly selective external and an internal with multiple invaginations, tubular or lamellar structures called cristae, which are connected by narrow tubular structures,...
In addition, the presence of signs of mitotic catastrophe—increase in cell size, micronucleation, and swirling of mitochondrial cristae—was detected. The antiproliferative effect of these AgNPs was more selective toward tumor cells compared with a nontumor cell line. Silver NPs also activated a ...
must be activated to phagocytose and process pathogens, migrate, proliferate, release soluble factors and destroy infected cells. Some of these functions are strongly dependent on lipid transfer, autophagosome formation, mitochondrial fission, and Ca2+flux; this indicates that MERCs could regulate ...
mitochondrial remodeling. But the proteins that shape mitochondrial cristae in these cells are still largely unclear. CYP11A1 can be a candidate protein associated with mitochondrial cristae structure because depletion of CYP11A1 leads to alteration of mitochondrial cristae and loss of tubulovesicular...
[3]. Unlike apoptosis, necrosis and autophagy, ferroptosis is an iron and ROS-dependent cell death having altered cytological characteristics, including deformed and ruptured outer mitochondrial membrane and reduced mitochondria cristae [61]. Such activities are due to the loss of plasma membrane ...
This then enhances mitochondrial protein import 19 (MIC19), causes mitochondrial cristae formation, and sustains cellular bioenergetics during conditions of high energy demand to maintain cellular survival and activity (Latorre-Muro et al. 2021; Fahie et al. 2022). Furthermore, the PERK located at...
Munoz-Gomez SA, Slamovits CH, Dacks JB, Baier KA, Spencer KD, Wideman JG. Ancient homology of the mitochondrial contact site and cristae organizing system points to an endosymbiotic origin of mitochondrial cristae. Curr Biol. 2015;25(11):1489-95....
stem cell maintenance stem cell activation mitochondrial dynamics aging Introduction Resident adult stem cells are essential for tissue homeostasis. Consequently, loss or dysfunction of adult stem cells is a unifying feature of many degenerative conditions and aging across many cell types (Almada and Wage...