LETM1 is a mitochondrial inner membrane protein that is required for maintaining the mitochondrial morphology and cristae structures, and regulates mitochondrial ion homeostasis. Here we report a role of LETM1 in the organization of cristae structures. We identified four amino acid residues of human...
LETM1 is a mitochondrial inner membrane protein that is required for maintaining the mitochondrial morphology and cristae structures, and regulates mitochondrial ion homeostasis. Here we report a role of LETM1 in the organization of cristae structures. We identified four amino acid residues of human...
Although gross mitochondrial fission and fusion seemed normal, ultrastructural studies revealed disorganized mitochondrial inner membrane. Inner membranes failed to form tubular or vesicular cristae and showed as closely packed stacks of membrane sheets that fused intermittently, resulting in a complex maze ...
Mitochondria are double membrane-bound organelles, composed of an inner (IMM) and an outer mitochondrial membrane (OMM), which separate the intermembrane space (IMS) from the matrix. The IMM extends internally to form cristae, which harbor essential macromolecular complexes such as the machinery ...
Mitochondria are double membrane-bound organelles, composed of an inner (IMM) and an outer mitochondrial membrane (OMM), which separate the intermembrane space (IMS) from the matrix. The IMM extends internally to form cristae, which harbor essential macromolecular complexes such as the machinery ...
The inner membrane mitochondrial protein (IMMT) is a central unit of the mitochondrial contact site and cristae organizing system (MICOS). While researchers continue to demonstrate the physiological function of IMMT in regulating mitochondrial dynamics and preserving mitochondrial structural integrity, the...
Cristae formation is a mechanical buckling eventcontrolled by the inner mitochondrial membrane lipidomedoi:10.15252/embj.2023114054Venkatraman, KailashLee, Christopher TGarcia, Guadalupe CMahapatra, ArijitMilshteyn, DanielPerkins, GuyKim, Keun‐Young...
Mitochondrial cristae are critical for efficient oxidative phosphorylation, however, how cristae architecture is precisely organized remains obscure. Here, we discovered that SAM complex directly interacts with MICOS complex to form a supercomplex, SAMICOS, which bridges mitochondrial outer- and inner-...
The mitochondrial inner membrane consists of two functionally and compositionally distinct subcompartments: cristae, which are inner membrane invaginations that accommodate the respiratory chain complexes and the inner boundary membrane, which is closely apposed to the outer membrane. These subcompartments ...
Here, we discovered that Mic19, a core component of MICOS (mitochondrial contact site and cristae organizing system) complex, can be cleaved at N-terminal by mitochondrial protease OMA1 under certain physiological stresses. Mic19 directly interacts with mitochondrial outer-membrane protein Sam50 (...