A further possible explanation for reduced POMC-neuron activity might be a generally reduced number of mitochondria due to increased mitophagy induced by Ca2+ overload [71]. Anyhow, a substantial reduction in α-MSH secretion and abundance, rescued by Ru360 inhibition of MCU, was reported in ...
5). The z-shift of 45 nm as well as dispersion measured with MTR- and MTG-labeled mitochondria in live cells only have a very minor effect of ~1.6 nm with regard to the x/y measurements (Supplementary Figs. 6 and 7). Other proteins of the MCU-Complex (i.e., MCU, EMRE and...