When a high-flux metabolic pathway branches into a lower-flux pathway, the ability to maintain activity of the latter is maximized when flux through the former is highest. In proliferating cells, this has been proposed as a way to resolve the apparent paradox between the need for glucose-...
Colon cancer is a leading cause of cancer-related mortality for which targeted therapy is needed; however, trials using apoptosis-inducing ligand monotherapy to overcome resistance to apoptosis have not shown clinical responses. Since colon cancer cells selectively uptake and rapidly metabolize glucose, ...
Metastatic dissemination occurs very early in the malignant progression of a cancer but the clinical manifestation of metastases often takes years. In recent decades, 5-year survival of patients with many solid cancers has increased due to earlier detection, local disease control and adjuvant therapies...
Antibodies targeting PD-1 or PD-L1 have had impressive and durable effects in a small subset of patients with certain types of cancer. This has been instrumental in fuelling the current excitement surrounding IO therapies, but many patients are resistant, or only respond transiently, to these ...
Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy has demonstrated encouraging outcomes in CRC, its benefits are minimal in CRLM. The complex immune landsca
Cancer cachexia has been defined as ‘a multi-factorial syndrome characterised by an ongoing loss of skeletal muscle mass, with or without a loss of fat mass, that cannot be fully reversed by conventional nutritional support...
Cancer Cell. 2002;2(5):353–61. Article CAS Google Scholar Zhang L, Chen J, Zhou X, Chen X, Li Q, Tan H, Dong X, Xiao Y, Chen L, Chen W. Dynamic metabolic and transcriptomic profiling of methyl jasmonate-treated hairy roots reveals synthetic characters and regulators of lignan ...
metabolic heterogeneity is responsible for the failure to induce the same therapeutic effect against cancer cells as a whole. In particular, cancer stem cells exhibit several biological features responsible for resistance to conventional anti-tumor therapies. Consequently, cancer stem cells tend to form ...
However, these microbes may influence responses to other forms of therapy as well and may also affect treatment-associated toxicity. Based on these influences, there is growing interest in targeting these microbes in the treatment of cancer and other diseases. Yet complexities exist, and a deeper ...
M. Immune checkpoint blockade: a common denominator approach to cancer therapy. Cancer Cell 27, 450–461 (2015). CAS PubMed PubMed Central Google Scholar Homey, B., Muller, A. & Zlotnik, A. Chemokines: agents for the immunotherapy of cancer? Nat. Rev. Immunol. 2, 175–184 (2002)....