Cancer metabolism: a therapeutic perspective. Nat Rev Clin Oncol. 2017; 14(1):11-31.Martinez-Outschoorn, U.E.; Peiris-Pages, M.; Pestell, R.G.; Sotgia, F.; Lisanti, M.P. Cancer metabolism: A therapeutic perspective. Nat. Rev. Clin. Oncol. 2016. [CrossRef] [PubMed]...
Cancer MetabolismSection edited by Violena Pietrobon and Mia Stanic Tumor cells reprogram nutrient acquisition and metabolic pathways to support abnormal growth and metastasis, a dysfunctional process that is a hallmark of cancer. The Cancer Metabolism section will offer a solid framework to promote ...
From a therapeutic perspective, the aberrant metabolism of proliferating cancer cells presents potential opportunities, and there has been a growing interest in studying how best to target cancer metabolism (Bobrovnikova-Marjon and Hurov, 2014, Galluzzi et al., 2013, Martinez-Outschoorn et al., ...
P. Cancer metabolism: a therapeutic perspective. Nat. Rev. Clin. Oncol. 14, 11–31 (2017). CAS PubMed Google Scholar Wolpaw, A. J. & Dang, C. V. Exploiting metabolic vulnerabilities of cancer with precision and accuracy. Trends Cell Biol. 28, 201–212 (2018). CAS PubMed Google ...
Interestingly, stromal cells showed a >4-fold expression of TDO2 in 12/20 and 8/20 tumor types as compared to cancer and normal cells, respectively. Other genes in the tryptophan metabolism pathway, IL4I1, KYNU, KMO, and CYP1B1 also showed a >2-fold upregulation in stroma as compared...
Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. The aberrant glucose metabolism is associated with dramatically increased bioenergetics, biosynthetic, and redox demands, which is vital to maintain rapid cell proliferation, tumor progression, and resistance to chemotherapy and...
Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosph
(CLEC-2 receptor) and its activator, podoplanin, a key protein in platelet aggregation, have attracted the interest of the scientific community [14,15]. Additional attractive targets for antiplatelet treatment involve arachidonic acid (AA) metabolism, cyclooxygenase (COX) and lipoxygenase (LOX) ...
In addition, the review provides insights for the development of therapeutic approaches and the discovery of natural substances that will be able to simultaneously inhibit several key oncological and inflammation-related targets. Keywords: cancer; inflammation; oxidative stress; metabolism; cytokines; HIF1...
Cancer stem cells (CSCs) are a sub-population of tumour cells, which are responsible to drive tumour growth, metastasis and therapy resistance. It has recently been proposed that enhanced glucose metabolism and immune evasion by tumour cells are linked, and are modulated by the changing tumour mi...