Although targeting HIF-1 as a cancer therapy seems like an extremely rational approach, owing to the complex network of its downstream effector genes, the development of specific HIF-1 inhibitors with fewer side effects and more specificity has not been achieved. Therefore, in this review, we ...
There is a complex and strong association between metabolic reprogramming and the phenomenon of drug resistance in cancer. Cancer cell metabolic modifications and crosstalk with cellular and noncellular components are essential to support their growth and proliferation and support anticancer therapy resistance...
The end-product of glycolysis is pyruvate, which may be metabolised to lactate and exported out of the cell. The net gain from anaerobic glycolysis is 2 ATP per glucose molecule. In humans, normal cells can run on anaerobic glycolysis for a few minutes; however, cancer cells may re...
May 2018 update: The answer to my question at the end of this post is “Yes it seems that you can get into ketosis on a plant-based diet.” Check out Miriam Kalamian and her “Keto for Cancer” bookhere.Long overnight fasts seem to be a good way to kickstart the process. Lupper...
Facebook Twitter Google Share on Facebook metabolic profiling The assessment of biochemical intermediates in tissues, which is used to describe metabolic pathways. Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved. Want to thank TFD for its existence?Tell a friend about us, ...
View chapterExplore book New markers in metabolic syndrome Da-HyeSon, ...Yong-JaeLee, inAdvances in Clinical Chemistry, 2022 Abstract Metabolic syndrome(MetS) is increasing globally and is clinically significant due to its association with cardiovascular disease,type 2 diabetesand cancer. Although the...
Int. J. Cancer 91, 180–186 (2001). Article CAS PubMed Google Scholar Oliver, S. G. Functional genomics: lessons from yeast. Phil. Trans. R. Soc. Lond. B 357, 17–23 (2002). Article CAS Google Scholar Kell, D. B. & Westerhoff, H. V. Towards a rational approach to the ...
leading to increased mutability, was considered the essential enabling characteristic for manifesting the six hallmarks [6]. However, the mutation rate for most genes is low making it unlikely that the numerous pathogenic mutations found in cancer cells would occur sporadically within a normal human ...
leading to increased mutability, was considered the essential enabling characteristic for manifesting the six hallmarks [6]. However, the mutation rate for most genes is low making it unlikely that the numerous pathogenic mutations found in cancer cells would occur sporadically within a normal human ...
Part of the book series: Molecular and Translational Medicine ((MOLEMED)) 443 Accesses Abstract Patients with pancreatic cancer (PDAC) are usually diagnosed in advanced often incurable disease stages. Sensitive and specific markers are critical to support diagnostic and therapeutic management. Early no...