The effect of radiation therapy on substrate metabolism was evaluated in five patients with head and neck or lung cancer. Stable isotope tracer methodology was used to determine urea, amino acid, glucose, and lipid kinetics during postabsorptive conditions before initiation, near the midpoint (after...
Cancer-specific isoforms of enzymes involved in energy metabolism, anabolism and adaptation to low oxygen may be new druggable targets for cancer therapy with potentially improved therapeutic indices compared with current therapy. Abstract Cancer therapy has long relied on the rapid proliferation of tumour...
In this Review Article, we will discuss the progress to date in design and delivery of unnatural sugars for metabolic labelling of tumour cells and subsequent development of tumour-targeted therapy. Metabolic cell labelling for cancer immunotherapy will also be discussed. Finally, we will provide a...
Many parallels exist between the metabolic profiles of cancer cells and normal proliferating cells, including the use of aerobic glycolysis, selective expression of metabolic enzymes with distinct regulatory features, and elevation of amino acid consumption and biosynthesis [1–6]. Growing tumors, like ...
Besides, modulating lipid metabolism in stromal cells and immune cells also provides a new choice for anti-tumor therapy. Moreover, it can be combined with chemotherapy and immunotherapy, providing a new comprehensive strategy for optimizing cancer treatment. This review aims to clarify the lipid ...
5. Nanocarriers for effective therapeutic delivery 6. Overview on systemic and localized drug delivery 7. Targeting cervical cancer through nanocarriers (NCs) 8. Lipid-based nanocarriers 9. Phyto-nanomedicines against cervical cancer 10. A brief overview of photothermal/radiation/gene therapy 11. Challe...
CAR T cells are widely applied for relapsed hematological cancer patients. With six approved cell therapies, for Multiple Myeloma and other B-cell malignancies, new insights emerge. Profound evidence shows that patients who fail CAR T-cell therapy have, aside from antigen escape, a more glycolytic...
"Through this collaborative, 18-month process, we identified and rapidly advanced IACS-10759 as the molecule for clinical development," said Di Francesco. "We believe IACS-10759 will provide a promising new therapy forcancerpatients." The pre-clinical research conducted by IACS and CCCT led to ...
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