promising targets for cancer therapy. Inhibition of PKM2 and fatty acid synthase (FASN) effectively induces apoptosis in cancer cells while sparing normal cells [29,46]. Isocitrate dehydrogenase (IDH), an essential enzyme in the TCA cycle, is required for cellular respiration. Mutations in IDH1/2...
KA Menear,S Gomez,K Malagu,... - 《Bioorganic & Medicinal Chemistry Letters》 被引量: 92发表: 2009年 Metabolic complications with the use of mTOR inhibitors for cancer therapy: A systematic review and meta-analysis. Purpose To provide guidelines on antimicrobial prophylaxis for adult neutropenic...
Many parallels exist between the metabolic profiles of cancer cells and normal proliferating cells, including the use of aerobic glycolysis, selective expression of metabolic enzymes with distinct regulatory features, and elevation of amino acid consumption and biosynthesis [1–6]. Growing tumors, like ...
Scheme 1. A general kinetic model for the HDAC8-catalyzed reaction with the substrate and the activator. Adapted from [21]. 4. HDAC8 as a target in cancer therapy HDAC8 is one of the insightful therapeutic anticancer targets and has been overexpressed in a range of human cancers [13].As...
5. Nanocarriers for effective therapeutic delivery 6. Overview on systemic and localized drug delivery 7. Targeting cervical cancer through nanocarriers (NCs) 8. Lipid-based nanocarriers 9. Phyto-nanomedicines against cervical cancer 10. A brief overview of photothermal/radiation/gene therapy 11. Challe...
the most significant contribution to the prevention of T2DM complications.10Furthermore, 160 participants with T2DM and microalbuminuria (with a mean age of 55) were randomized and allocated to undergo either conventional or intensive therapy in the Steno-2 trial, and they were followed for the mea...
Indeed, differential metabolic reprogramming can potentially regulate cancer stemness, differentiation, and cell fate30. As a result, many aspects of rewired metabolism can provide therapeutic liabilities within tumors that can be effectively leveraged for therapy. In this study we seek to elucidate the...
Cucurbitacins - a promising target for cancer therapy. Int J Health Sci (Qassim). 2013;7(1):77–89. PubMed Google Scholar Hoque TS, Hossain MA, Mostofa MG, Burritt DJ, Fujita M, Tran LSP. Methylglyoxal: an Emerging Signaling Molecule in Plant Abiotic stress responses and tolerance. ...
the mutation rate for most genes is low making it unlikely that the numerous pathogenic mutations found in cancer cells would occur sporadically within a normal human lifespan [7]. This then created another paradox. If mutations are such rare events, then how is it possible that cancer cells...
(FA) serves as a tumor-targeting ligand, selectively binding to folate receptors overexpressed on the surface of cancer cell. Liu et al. reported that ZnMnFe2O4-PEG-FA nanoplatform possessing photothermal and POD-like activity was developed for tumor therapy via synergistic tumor cell diagnosis ...