FerroptosisHypoxiaHypoxia-inducible factorLipid peroxidationSystem XcFerroptosis is a new form of programmed cell death, which is characterized by the iron-dependent accumulation of lipid peroxidation and incre
It has been widely regarded as a protective factor for tumor cells to resist ferroptosis [18,19]. However, the molecular mechanisms by which HIF-1α affects ferroptosis remain unclear. We believe that exploring the mechanisms underlying HIF-1α/ferroptosis during hypoxia is of great significance ...
2. Molecular mechanism of ferroptosis The regulatory mechanisms of ferroptosis are intricate, involving a series of signaling. molecules and metabolic pathways. We summarize the current significant factors of iron, amino acid, lipid metabolism and related pathways in the pathogenesis of ferroptosis (Fig...
The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation. Here, we identify an additional activity of R-2-HG: tumor cell–derived R-2-HG is taken up by
Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are frequently detected in cancers of various origins, including but not limited to acute m
ferroptosis is intimately associated with cancer initiation, progression, and suppression. In this review, we summarize the primary mechanisms and signal pathways relevant to ferroptosis and then discuss the potential roles of ferroptosis in cancer, including those related to p53, noncoding RNA (ncRNA)...
mechanisms. Active compounds from Chinese herbs and other natural sources exhibit anti-inflammatory, antioxidant, antitumor, and immunomodulatory effects, making them valuable in preventing and treating respiratory conditions. Ferroptosis, a unique form of programmed cell death (PCD) distinct from apoptosis...
These processes are important for the maintenance of mitochondrial homeostasis, and alterations in the mitochondrial function and signaling are known to contribute to the dysregulation of cell death pathways. Recent studies have uncovered regulatory mechanisms that control the activity of the key components...
Roles of OGT in the regulation of apoptosis, cancer stem-like cells properties, ferroptosis and immune escape in cancer Full size image Roles of OGT in cancer stem-like cells properties Tumor initiation and progression are regulated by cancer stem cells (CSCs), which possess self-renewal, plastic...
The main regulatory mechanisms of ferroptosisIn contrast to other types of cell death, the characteristics of ferroptosis mainly manifest as iron overload and lipid peroxide accumulation. During the process of renal injury, in addition to the classical abnormal regulation of iron metabolism and lipid ...