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Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release
In principle, tissue clearing is achieved by reducing light scattering through a combination of lipid removal, size change, and matching of the refractive index (RI) between the imaging solution and the tissue. However, the contributions of these major factors in tissue clearing have not been ...
the present study identified a subset of fibroblasts and smooth muscle cells which are the major constituents of organ stroma neither proliferative nor senescent in tissues of the elderly, which we termed “mid-old status” cells. Upregulation of pro-inflammatory genes...
Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote tum
Small leucine-rich proteoglycans (SLRPs) are the major non-collagen component of ECM, playing a vital role in cancer progression, metastasis, cardiac remodeling, osteoarthritis (OA), tissue morphogenesis, and immune response. SLRPs consist of 17 members, classified into V classes based on ...
Most cells migrate through a dense three-dimensional extracellular matrix (ECM) composed of a complex mixture of proteins and macromolecules. The only way cells can change their shape, rearrange themselves, and eventually migrate is for this dense, complex matrix to get restructured and remodeled by...
My chosen subject brings together my interest in two remote structures in the eye together with a technology, which has had a major impact throughout the globe, lasers. It would also appear to be the first Bowman's lecture to spend a significant amount of time describing research on Bowman'...
The ECM composition and integrity are key determinants of the physical characteristics of the aortic wall. Vascular ECM undergoes continuous physiological remodeling, whereby the existing ECM proteins are proteolytically degraded to be replaced by newly synthesized proteins. Several protease families are invo...
Proteoglycans are one of the major macromolecules found in articular cartilage. These molecules consist of a core protein and covalently attached glycosaminoglycans (GAG) chains. The GAGs are long, unbranched heteropolysaccharides, consisting of repeated disaccharide units, with the general structure: Mur...