Long-term potentiation (LTP) is the most widely studied form of neuroplasticity and is believed by many in the field to be the substrate for learning and memory. For this reason, an understanding of the mechanisms underlying LTP is thought to be of fundamental importance to the neurosciences, ...
Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science 275, 213–215 (1997). Article CAS PubMed Google Scholar Malenka, R. C. The long-term potential of LTP. Nat. Rev. Neurosci. 4, 923–926 (2003). Article CAS PubMed Google Scholar Nabavi, S. et ...
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Having determined that the differential surface levels of RET and TrkB might be due to the intracellular domain, we then sought to determine whether there was a key motif responsible for this difference. The ratiometric fluorescence assay was used to define the potential regions in the RET receptor...
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These studies stress the general neuroprotective role of IL-6 in the central nervous system. However, as a consequence of the deficit in glutamate signaling the induction of long-term potentiation (LTP) is inhibited by IL-6, which may negatively affect memory formation and cognitive performance [...
Potential hazards by formation of silver acetylide upon aspirating solution containing high concentrations of silver to an atomic-absorption... Racine RJ, Wilson DA, Gingell R, Sunderland D (1986) Long-term potentiation in the interpositus and vestibular nuclei in the rat. Exp Brain Res 63:.....
of a change in receptor number includes the increase in mEPSC amplitude and in the response to glutamate application. It is unclear whether the homeostatic regulation of receptor numbers shares a signalling pathway with the insertion of receptors into the membrane by long-term potentiation (LTP). ...
Here we introduce a model of synaptic plasticity based on data-constrained postsynaptic calcium dynamics, and show in a neocortical microcircuit model that a single parameter set is sufficient to unify the available experimental findings on long-term potentiation (LTP) and long-term depression (LTD)...
Ion channel properties underlying axonal action potential initiation in pyramidal neurons. Nature Neurosci. 5, 533–538 (2002). Article CAS PubMed Google Scholar Westenbroek, R. E., Merrick, D. K. & Catterall, W. A. Differential subcellular localization of the RI and RII Na+ channel ...