Malenka RC (2003) The long-term potential of LTP. Nature Reviews Neuroscience 4:923-926.Malenka, R. C. (2003). The long-term potential of LTP. Nat. Rev. Neurosci., Vol.4, No.11, pp. 923-6.Malenka, R.C. (2003) The long-term potential of LTP. Nat. Rev. Neurosci., 4, ...
在学习和记忆过程中,神经元之间的突触连接会发生改变,这一过程被称为突触可塑性。例如,长时程增强(Long-Term Potentiation, LTP)是突触传递效率提高的一种形式,与记忆形成紧密相关。 分子层面上,一系列信号传导途径被激活,包括CREB蛋白的磷酸...
Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science 275, 213–215 (1997). Article CAS PubMed Google Scholar Malenka, R. C. The long-term potential of LTP. Nat. Rev. Neurosci. 4, 923–926 (2003). Article CAS PubMed Google Scholar Nabavi, S. et ...
There is great interest in understanding the mechanisms of expression underlying long-term potentiation (LTP). They are agreed to involve an increase in synaptic efficacy, which is described by three multiplicative parameters: p, the probability of neurotransmitter release; n, the number of active re...
We have used quantitative electron microscopy to study synaptophysin (Syn) immunolabelling in the hippocampus of adult rats 24h after induction in vivo of long term potentiation (LTP), and long term depression (LTD). Electrodes were implanted chronically in hippocampus with stimulation at either the...
此外,这种结合的发生被一种特殊的受体,即NMDA(N–甲基–D–天冬氨酸)谷氨酸受体所识别。它触发了长时程增强(long-term potentiation,简称LTP),其起效迅速而且持续时间长,是一种很好的长期记忆基质。与玻尔兹曼机学习算法(见方框7.2)十分相似,突触上的赫布可塑性是由输入和输出之间的一致性决定的。
Synaptic function, as represented by the long-term potentiation (LTP) of synaptic transmission in the Schaffer collateral synapses (CA3-CA1) of Ts2 mice, was improved modestly (p = 0.0334, 18% increase in fEPSP slope at 110 minutes) by neflamapimod treatment (Fig.2a–c). Behavioral...
LONG-TERM POTENTIATIONAFTERDISCHARGEKINDLINGWORKING MEMORYLOW-FREQUENCY STIMULATIONEVOKED POTENTIALIn this study, the terminal complement complex c5b-9 (TCC) was... G Stoll,B Schmidt,S Jander,... - 《Annals of Neurology》 被引量: 121发表: 2010年 Hippocampal long‐term depression as an index of...
The late stage of long-term potentiation (LTP) and long-term memory is believed to be largely governed by altered gene expression for its generation and maintenance, while the early stages of LTP and memory are controlled mainly by the phosphorylation-dephosphorylation of the synaptic proteins. For...
The study of synaptic plasticity has revealed a common cascade of ultrastructural events across several paradigms. Most notable of these paradigms are development, long-term potentiation (LTP), and adult reactive synaptogenesis (RS). These plastic neural events are discussed in terms of major categorie...