The Hydrolysis of Atp That Accompanies Actin Polymerization Is Essentially Irreversible. FEBS Lett. 235:211-214.Carlier M-F, Pantaloni D, Evans JA, Lambooy PK, Korn ED, Webb MR. The hydrolysis of ATP that accompanies actin polymerization is essentially irreversible. FEBS Lett 1988; 235: 211-...
The enzyme F-adenosine triphosphatase (ATPase) is a molecular motor that converts the chemical energy stored in the molecule adenosine triphosphate (ATP) into mechanical rotation of its -subunit. During steady-state catalysis, the three catalytic sites of F operate in a cooperative fashion such tha...
states of MutS as reflected in: (i) a specific and highly stable MutS–mismatch complex in the absence of a nucleotide; (ii) a specific but less stable complex in the presence of ATP hydrolysis; and (iii) an irreversibly dissociated complex in the presence of ATP binding (ATPγS). Such...
S. The full-length structure of Thermus scotoductus OLD defines the ATP hydrolysis properties and catalytic mechanism of class 1 OLD family nucleases. Nucleic Acids Res. 48, 2762–2776 (2020). Article CAS PubMed PubMed Central Google Scholar Cheng, R. et al. Prokaryotic Gabija complex ...
Mg ATP actin saturated with profilin can elongate barbed ends at >60 s(-1), 2 orders of magnitude faster than ATP hydrolysis (0.3 s(-1)). Given that profilin binds to a surface on actin that is buried in the Holmes model of the actin filament, we expect that profilin will block ...
We perform molecular dynamics simulations with two conformations of ABC transporters. Dynamics of the ATP/ATP and ATP/ADP bound outward-facing conformations differs. Outward-facing conformation can switch to MsbA-like bottom-closed apo conformation. The inward-facing structure may be a short-living tr...
The main mechanism of P-gp induced drug resistance is associated with the use of energy released by ATP hydrolysis to pump the neoadjuvant chemotherapy drugs out of the cell, so that the drug concentration is lower than the effective concentration [21]. Relevant studies have shown that ...
2000, Physiological Reviews The Influence of Respiration and ATP Hydrolysis on the Proton‐Electrochemical Gradient across the Inner Membrane of Rat‐Liver Mitochondria as Determined by Ion Distribution 1974, European Journal of Biochemistry View all citing articles on Scopus☆ Dedicated to Professor H. ...
of enzymes, motor proteins, and transport proteins to carry out the work of the cell. Also, the hydrolysis yields free inorganic phosphate and adenosine diphosphate, which can be broken down further to another phosphate ion and adenosine monophosphate. ATP can also be broken down to adenosine ...
The biosynthesis of peptides involves aminoacyl adenylates (aa-AMPs), formed through the reaction of ATP with α-amino acids (aas) (Fig. 1), that are subsequently used to aminoacylate tRNA. Their standard free energy of hydrolysis value ΔG°′ =ca. −70 kJ mol−1, determined for...