The Human Transcription Factors. Cell 2018, 172, 650-665. [CrossRef] [PubMed]Lambert SA, Jolma A, Campitelli LF, Das PK, Yin Y, Albu M, et al. The Human Transcription Factors. Cell 2018 Feb;172(4):650-665. http://linkinghub.elsevier.com/retrieve/pii/S0092867418301065....
transcriptionhumantfsfactorsbindingcincinnati LeadingEdgeReviewTheHumanTranscriptionFactorsSamuelA.Lambert,1,9ArttuJolma,2,9LauraF.Campitelli,1,9PratyushK.Das,3YimengYin,4MihaiAlbu,2XiaotingChen,5JussiTaipale,3,4,6,*TimothyR.Hughes,1,2,*andMatthewT.Weirauch5,7,8,*1DepartmentofMolecularGenetics,Universi...
Importantly, these reports elaborate on important limitations of using GEMMs such as patient specific mutations within transcription factors that are poorly correlated to human disease3,52,53,54. In MAFB KO mice, β-cell formation is merely delayed while α-cells are severely compromised, with no ...
The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19) has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical trials of mRNA therapeutics include studies of paracrine vascular endothelia
AI transcription: Transcription is moving in the AI-only direction at whip speed. Every app I tested has automated transcription available—it's fast, easy, and convenient. Human transcription is great as an add-on feature—especially for industries with plenty of technical jargon—but I didn't...
A notable decrease in anthocyanins accumulation in Yunyan 87 mutant tobacco was attributed to the coordinated downregulation of anthocyanin biosynthetic genes including CHI, F3H, DFR, UFGT, as well as several genes encoding MYB and bHLH transcription factors [38]. Thirteen anthocyanin biosynthetic-...
A direct relationship between these two was reported, as Snai1 targets miR-145 promoter and represses its transcription, while overexpression of miR-145 downregulated this transcription factor. miR-145 was also shown to target important stem cell factors such as KLF4, c-Myc, Nanog, or OCT4. ...
Moreover, Akt can negatively regulate transcription factors, such as NF-κB or FOXO, and increase the production of antiapoptotic and prosurvival genes [43,45,48]. In addition to the inhibition of apoptosis, Akt also regulates cell survival through p27, GSK3, or the mTOR complex. To ...
aTo generate iPS cell lines from mouse renal tubular epithelial cells (mRTECs), four transcription factors (OCT-4, SOX-2, KLF-4, and c-MYC) were introduced using lentiviral vectors at a multiplicity of infection of 15 正在翻译,请等待...[translate] ...
Leading EdgeReviewThe Human Transcription FactorsSamuel A. Lambert, 1,9 Arttu Jolma, 2,9 Laura F. Campitelli, 1,9 Pratyush K. Das, 3 Yimeng Yin, 4 Mihai Albu, 2 Xiaoting Chen, 5Jussi Taipale, 3,4,6, * Timothy R. Hughes, 1,2, * and Matthew T. Weirauch 5,7,8, *1 Department...