The Human Transcription Factors. Cell 2018 Feb;172(4):650-665. http://linkinghub.elsevier.com/retrieve/pii/S0092867418301065.Lambert SA, Jolma A, Campitelli LF, Das PK, Yin Y, Albu M, Chen X, Taipale J, Hughes TR, Weirauch MT (2018) The human transcription factors. Cell 172: 650 -...
Figure 2. DNA-Binding Specificities of the Human Transcription Factors (A) Heatmap showing similarity of human TF DNA binding motifs. Representative motif(s) were selected for each TF from the set of motifs directly determined by a high-throughput in vitro assay. Pairwise motif similarities were...
How Transcription Factors Are Identi,ed The major TF fami l ies in eukaryotes, such as C2H2-zinc,nger (ZF),Homeodomain,basichel ix-loop-hel ix(bHLH),basic leucine zipper(bZIP),and nuclearhormone receptor (NHR),were initial ly described in the 1980s (reviewed in Johnson and McKnight...
It's not hard to find AI transcription software—the market is saturated with it. But it is hard to figure out which one to use. Most transcription tools are neck-and-neck in accuracy, so it's the additional features (and cost) that distinguish them. I spent several weeks testing ...
One such factor is MAFB, which has been identified in numerous studies to be expressed within adult human β-cells, while being absent from the murine counterparts. MAFB is a member of the large Maf family of transcription factors that share highly similar basic region/leucine zipper DNA binding...
Regulation of transcription upon heat shock timecourse in human K562 cells. a Illustration of the regulatory changes (red arrows) at a model gene upon heat shock. Pol II is depicted in silver, decorated with initiation, pausing or elongation factors (dark gray). b Experimental setup of the he...
Leading EdgeReviewThe Human Transcription FactorsSamuel A. Lambert, 1,9 Arttu Jolma, 2,9 Laura F. Campitelli, 1,9 Pratyush K. Das, 3 Yimeng Yin, 4 Mihai Albu, 2 Xiaoting Chen, 5Jussi Taipale, 3,4,6, * Timothy R. Hughes, 1,2, * and Matthew T. Weirauch 5,7,8, *1 Department...
“the whole transcription life,” he sighs, “has gone to garbage.” (gabriel is not his real name, though you probably figured that out. he doesn't want to burn bridges.) why do i raise the seemingly arcane subject of transcription? because if you want to understand the future of ...
Moreover, analysis of pseudogene transcription on human chr. 22 using a combined bioinformatic/microarray approach demonstrated that up to 20% of the pseudogenes identified on this chromosome are transcriptionally active [25]. The surprisingly high proportion of potentially transcribed pseudogenes questions...
Among these challenging samples are large eukaryotic transcription complexes, which suffer from all such shortcomings. Here we report how we have recently tried to overcome those challenges in order to improve our structural understanding of the human transcription pre-initiation complex assembly and the...