Alzheimer's disease (AD) is a cognitive disease with high morbidity and mortality. In AD patients, the diversity of the gut microbiota is altered, which influences pathology through the gut鈥揵rain axis. Probiotic therapy alleviates pathological and psychological consequences by restoring the diversity...
Alzheimer’s disease (AD), the most common cause of dementia, results in a sustained decline in cognition. There are currently few effective disease modifying therapies for AD, but insights into the mechanisms that mediate the onset and progression of disease may lead to new, effective therapeutic...
Alzheimer’s disease (AD), the most common cause of dementia, results in a sustained decline in cognition. There are currently few effective disease modifying therapies for AD, but insights into the mechanisms that mediate the onset and progression of disease may lead to new, effective therapeutic...
Alzheimer’s disease (AD) is the most common form of dementia without effective clinical treatment. Here, we show that intermittent fasting (IF) improves cognitive functions and AD-like pathology in a transgenic AD mouse model (5XFAD). IF alters gut microbial composition with a significant enrich...
Alzheimer’s disease bile acids microbiota–gut–brain axis molecular mechanism therapeutic strategy 1. Introduction Alzheimer’s disease (AD) is a neurodegenerative disorder with a high incidence and high disability rate among the elderly, affecting over 50 million individuals worldwide. This number is...
Alzheimer's disease (AD) is the most common neurodegenerative disease and its pathogenesis is still unclear. There is dysbiosis of gut microbiota in AD patients. More importantly, dysbiosis of the gut microbio... Authors: Xiao-hang Qian, Xiao-li Liu, Guang Chen, Sheng-di Chen and Hui-dong...
Although several studies have been conducted to unravel the possible relationship between Alzheimer's Disease (AD) pathogenesis and progression, the diagnostic and therapeutic potential of approaches aiming at restoring gut microbiota eubiosis remain to be fully addressed. In this narrative review, we ...
Journal: Frontiers in Cellular Neuroscience Publisher: Frontiers Media S.A. Keywords: Alzheimer's disease, evolution, gastrointestinal, innate immune response and inflammation, Metchnikoff, neuro-inflammation, probiotics, symbiosis Read this article at ScienceOpenPublisherPMC ...
Alzheimer’s disease (AD) is a complex disorder influenced by both genetic and environmental components and has become a major public health issue throughout the world. Oxidative stress and inflammation play important roles in the evolution of those majo
The Emerging Role of Metabolism in Brain-Heart Axis: New Challenge for the Therapy and Prevention of Alzheimer Disease. May Thioredoxin Interacting Protein... TXNIP is a key regulator of metabolism at both cellular and body level and it exerts also a pathological function in several cardiovascular...