Summary: Researchers are pioneering the use of artificial intelligence to explore how the gut microbiome influences Alzheimer’s disease. Their latest study employs AI to analyze how metabolites produced by gut bacteria interact with cellular receptors, potentially contributing to Alzheimer’s development....
Structural and functional alterations to the gut microbiome, referred to as gut dysbiosis, have emerged as potential key mediators of neurodegeneration and Alzheimer disease (AD) pathogenesis through the "gut -brain" axis. Emerging data from animal and clinical studies support an important role for ...
Alzheimer’s disease (AD), the most common cause of dementia, results in a sustained decline in cognition. There are currently few effective disease modifying therapies for AD, but insights into the mechanisms that mediate the onset and progression of disease may lead to new, effective therapeutic...
Alzheimer’s disease (AD) is the most common form of dementia. However, the etiopathogenesis of this devastating disease is not fully understood. Recent studies in rodents suggest that alterations in the gut microbiome may contribute to amyloid deposition, yet the microbial communities associated with...
A growing body of evidence suggests that dysbiosis of the human gut microbiota is associated with neurodegenerative diseases like Alzheimer’s disease (AD) via neuroinflammatory processes across the microbiota-gut-brain axis. The gut microbiota affects b
It's known that amyloid-beta and tau begin to accumulatelong before the onsetof Alzheimer's symptoms. It's at this stage (known as the "preclinical stage") that the researchers saw changes in the gut microbiome. The researchers found distinct differences in the gut microbiome profiles of olde...
Nasal microbiome Nasal microbiota predictors for methicillin resistant Staphylococcus colonization in critically ill children –Kathleen Zani – PlosOne Animal experiments Fecal Microbiota Transplantation (FMT) From a Human at Low Risk for Alzheimer’s Disease Improves Short-Term Recognition Memory and Increas...
and infections [5,6]. The observation that germ-free mice are protected from development of experimental arthritis [7] suggests a possible role for the microbiome in the pathogenesis of this disease. The composition of the gut microbiota in RA patients free of therapy is severely altered compared...
doi:10.1016/B978-0-12-823485-3.00023-3E. PaleyProtein Biosynthesis Interference in Disease
The microbiome is mainly made up of bacteria, viruses, archaea, and fungi at the order of magnitude of a trillion microbes; as a result, the ratio is nearly 1:1 of bacterial to human cells in the body, although the genomic content of the microbiome contains more than 100-fold more genes...