fecal matter transplant from healthy donors into AD patients, microbiome modifying drugs, and direct targeting of gut microbiome controlled neuroinflammatory pathways may potentially be disease modifying therapeutic strategies and may reduce amyloid, tau, and neurodegeneration...
rich in healthy fats and protein with low carbohydrates, could lower the risk of Alzheimer’s disease. The researchers found that this diet led to significant changes in the gut microbiome and in a biological pathway related to Alzheimer’s disease, ...
Alzheimer’s disease (AD) is the most common form of dementia. However, the etiopathogenesis of this devastating disease is not fully understood. Recent studies in rodents suggest that alterations in the gut microbiome may contribute to amyloid deposition, yet the microbial communities associated with...
Our objective is to investigate this potential causal connection.#We obtained summary results from two significant genome-wide association studies (GWAS) on gut microbiota (the MibioGen consortium and the Dutch Microbiome Project), along with one GWAS summary result for AD. Using a two-sample ...
Firstly, the microbiome of the human GI tract is the largest reservoir of microbes in the body, containing about 1014 microorganisms; over 99% of microbiota in the gut are anaerobic bacteria, with fungi, protozoa, archaebacteria and other microorganisms making up the remainder. There is ...
A growing body of evidence suggests that dysbiosis of the human gut microbiota is associated with neurodegenerative diseases like Alzheimer’s disease (AD) via neuroinflammatory processes across the microbiota-gut-brain axis. The gut microbiota affects b
analyzed the data and wrote the manuscript. J.W. and Yang Liao provided assistance with animal behavioral tests. Y.W. performed electrophysiological recording. Z.L. provided assistance with the bioinformatic analysis of the gut microbiome. Yajin Liao, C.Z., Z.L., L.S. and J.Y. contributed...
The project, called AD-gut, will be coordinated by EPFL. The team led by EPFL Professors Aleksandra Radenovic, Dimitri Van de Ville and Théo Lasser will also work on developing various imaging techniques in order to decipher the microbiome along with theranostic methods aimed at revealing the ...
A second aim of the three-year research project is to investigate how probiotics and nutritional supplements, both of which contain friendly bacteria, can stamp out bad bacteria and stop metabolites escaping from the gut. This follows on from severalinternational clinical researchstudies that have dem...
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