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c Ki-67 index of myeloma cells. Slides were co-stained for CD138 (DAB) and Ki-67 (FastRed). Scale bar indicates 20 µm. The RBM and the FL of patient P13 are shown in the left panel. In the right panel a line plot is shown for the proportion of Ki67-positive plasma cells...
Triple-negative breast cancer (TNBC) treatment is challenging and frequently characterized by an aggressive phenotype and low prognosis in comparison to other subtypes. This paper presents fabricated implantable drug-loaded microporous poly-di-methyl-siloxane (PDMS) devices for the delivery of targeted t...
Summary of studies to define the therapeutic index (TI) of Org 214007-0.MarieJosé, C. van LieropWynand, AlkemaAnke, J. LaskewitzRein, DijkemaHans, M. van der MaadenMartin, J. SmitRalf, PlatePaolo, G. M. ContiChristan, G. J. M. Jans...
score that can predict the possibility of high-grade PC. This score is calculated using the formula: (TMPRSS2-ERG mRNA/PSA mRNA) × 100,000 [73]. TMPRSS2-ERG often combines with PCA3 to improve its predictability. The predictive value of this test is still under investigation [98]...
Immune checkpoint inhibitors (ICIs) have revolutionized cancer management and have been widely applied; however, they still have some limitations in terms of efficacy and toxicity. There are multiple treatment regimens in Traditional Chinese Medicine (TC
[ 10 , 11 ]. blood lipid levels play a crucial role as risk factors for heart failure. atherogenic index of plasma (aip) is a strong predictor for assessing the risk of atherosclerosis and coronary heart disease, calculated using the formula (log) tg/hdl-c [ 12 , 13 ]. the amount ...
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 treated) using single-cell/nucleus RNA sequencing, bulk-proteogenomics, spatial transcriptomics and cellular imaging. Subpopu...
She cooked potion (зелье), an anti-aging mixture, for Koschei and herself. Now we can compose this mixture by using available drugs. The cornerstone of the formula is a rapalog such as rapamycin. Yet, gerontologists claim that rapamycin cannot be used in humans because of its ...