Of note, the FDA has issued a guidance for advising on the statistical calculation of equivalence margins, which appears to be acceptable also to the EMA [52]. Accordingly, the statistically estimated margins should be based on available data for the originator in comparison with placebo or ...
1). On the basis of our recently reported geometric calculation estimates35, each 70 nm particle contained ∼1.8 × 105 VK1 molecules. Powder diffraction analysis of freeze-dried ss-InFroMs did not reveal any crystallinity, suggesting an unorganized stacking of VK1 in hydrophobic nano-phased...
Utilizing the signature calculation formula, patients from the TCGA cohort were stratified into high-risk and low-risk groups based on the median risk score. The analysis revealed a significantly higher proportion of patients experiencing biochemical recurrence (BCR) in the high-risk group compared to...
Chemotherapy and targeted therapy are the major treatments for gastric cancer (GC), but drug resistance limits its effectiveness. Here, we profile the proteome of 206 tumor tissues from patients with GC undergoing either chemotherapy or anti-HER2-based therapy. Proteome-based classification reveals fou...
The calculation used the α/β ratio of 10, to consider tumor radiobiology rather than that of normal tissues. It is important to optimize values of α/β in future studies, but currently it has still been common to use α/β = 3 Gy for some normal tissues and α/β = 10 ...
improvements were achieved in the models in terms of performance and calculation time. The feature transformations involved several steps for removing constant features, quasi-constant features (with threshold = 0.1), duplicate features and highly correlated features (with threshold ≥ 0.9). Ta...
Protein spot intensities were normalized to Z-scores before the calculation. The sample names used in this map are marked along the bottom. The dendrograms represent the independent clustering of samples and spots, respectively. Red cells represent higher than average level of protein expression ...
The calculation includes initial clearance and achieves good diagnostic performance (sensitivity 82–90%, specificity 80–87%). It is available online with free access (www.premedibd.com). Finally, calculating clearance dynamically enables us to identify patients highly suspected of having ...
For example, there are provided therapeutic kits comprising one to five doses of KAF156, or a pharmaceutically acceptable salt thereof, for daily administration, wherein said doses are of about 200 mg to about 1000 mg, e.g. about 200 mg, e.g. about 300 mg, about 350 mg, e.g. abou...
This information is then fed to the image processor 160 where digitization and calculation of an area are made to extract the position of the center of gravity of the calculus 152 which is then delivered to the location detector 161. The location detector 161 detects a difference between the ...