Virology The genomic evolution of human influenza A virus THE PENNSYLVANIA STATE UNIVERSITY NelsonMartha IThe genetic diversity and evolutionary plasticity of the influenza A virus poses a continual, yet unpredictable threat to public health. The notorious 1918 pandemic of 'Spanish flu' was associated ...
Viruses have evolved a multitude of strategies to subvert the innate immune system by interfering with components of the alpha/beta interferon (IFN-α/β) ... O.,Bauhofer,A.,... - 《Journal of Virology》 被引量: 325发表: 2007年 Internal Ribosome Entry Site Regulates Translation of Kaposi...
The evolutionary interaction between influenza A virus and the human immune system, manifest as ‘antigenic drift’ of the viral haemagglutinin, is one of the best described patterns in molecular evolution. However, little is known about the genome-scale evolutionary dynamics of this pathogen. Similar...
Influenza viruses are single-stranded, negative- sense RNA viruses of the family Orthomyxoviridae that cause regular seasonal epidemics in humans, other mammalian species and birds. Three phylogenetically and antigenically distinct viral types — A, B and C — circulate globally in human populations, ...
The evolution of human influenza viruses. The evolution of influenza viruses results in (i) recurrent annual epidemics of disease that are caused by progressive antigenic drift of influenza A and B... None - 《Philosophical Transactions of the Royal Society of London》 被引量: 885发表: 2001年...
We find that evolution away from existing human immunity results in rapid population turnover in the influenza virus and that this population turnover occurs primarily along a single antigenic axis. Conclusions Selective dynamics induce a canalized evolutionary trajectory, in which the evolutionary fate ...
The evolution of seasonal influenza viruses is an important source of disease burden, as it allows for the reinfection of previously infected or vaccinated individuals Given that 5–15% of the global human population is infected with seasonal influenza viruses each year, it is surprising that new ...
of influenza transmission and evolution. This new, large-scale sequencing effort promises to provide a more comprehensive picture of the evolution of influenza viruses and of their pattern of transmission through human and animal populations. All data from this project are being deposited, without ...
human and non-human influenza A viruses or by the accumulation of mutations in the non-human influenza virus. It is necessary to understand the evolutionary processes of influenza A viruses in various hosts so that we have better knowledge about the emergence of this pandemic virus. We conducted...
The success of many viruses depends upon cooperative interactions between viral genomes. However, whenever cooperation occurs, there is the potential for ‘cheats’ to exploit that cooperation. We suggest that: (1) the biology of viruses makes viral coop