This family of transcription factors was originally defined on the basis of the conserved primary sequence of their DNA-binding domains. The ETS DNA-binding domain is also conserved at the structural level and i
ETS-domain transcription factors are found in all metazoan organisms and are characterised by the presence of a conserved DNA-binding domain (the ETS-domain). Other domains provide additional functions to each protein, and contribute to their specificity of action at the molecular and biological leve...
The ETS-domain transcription factor family 2001, Nature Reviews Molecular Cell Biology Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence 2001, Nature Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity 2001,...
Our findings reveal that the ETS-family transcription factor PU.1 plays a crucial role in regulating basal and inducible FcγRIIB expression. Moreover, when co-expressed, PU.1 co-operates with the related ETS-family member SPIB to drive FcγRIIB expression. PU.1 binding to the proximal ...
The ETS-domain transcription factor family. Nat. Rev. Mol. Cell Biol. 2, 827–837 (2001). Article CAS Google Scholar Moreno, E., Yan, M. & Basler, K. Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr...
This chapter reviews the expression and role of Ets-genes during embryogenesis of amphibians and birds. In addition to overlapping expression domains, some of them exhibit cell type-specific expression. Many of them are expressed in migratory cells: neur
Findings over the past decade have identified aberrant activation of the ETS transcription factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene rearrangement and amplification, feed-forward growth factor signalling loops, formation of gain-of-function co-regulatory compl...
Transcription factors are essential for the development and regeneration of the nervous system. The current study investigated key regulatory transcription factors in rat spinal cord development via RNA sequencing. The hub gene Ets1 was highly expressed in the spinal cord during the embryonic period, ...
Regarding FOXP3’s regulation, it has been shown that various proteins (e.g. NFAT, AP-1, FOXO1, FOXO3, CREB-ATF1, SAMD3, RAR-RXR, RUNX, ETS1, STAT5) are capable of directly binding to its promoter and other regulatory regions to activate its transcription [179,180,181]. The TGFβ...
ETS family TFBSs, which we detected concentrated around the region immediately upstream of the TSS in 6 human and 9 mouse clusters (Table3, and Additional file1: Table S10), and NRF-1 binding sites, which we found in 4 human and 5 mouse clusters, here too in all cases in the region...