The ETS domain transcription factor family. Int. J. Biochem. Cell Biol. 29:1371-1387.Sharrocks AD. The ETS-domain transcription factor family. Nat Rev Mol Cell Biol 2001; 2:827-37; PMID:11715049; http://dx.doi.org/ 10.1038/35099076A.D. Sharrocks, The ETS-domain transcription factor ...
ETS-domain transcription factors are found in all metazoan organisms and are characterised by the presence of a conserved DNA-binding domain (the ETS-domain). Other domains provide additional functions to each protein, and contribute to their specificity of action at the molecular and biological leve...
The ETS-domain transcription factor family. Nat. Rev. Mol. Cell Biol. 2, 827–837 (2001). Article CAS Google Scholar Moreno, E., Yan, M. & Basler, K. Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr...
Elf3 is an epithelially restricted member of the ETS transcription factor family, which is involved in a wide range of normal cellular processes. Elf3 is also aberrantly expressed in several cancers, including breast cancer. To better understand the molecular mechanisms by which Elf3 regulates thes...
It could be shown that ETV6 is able to dimerize via its pointed domain with the ets-family transcription factor FLI1 [34]. In this context, ETV6 is able to repress the transcriptional activity of FLI1 [34]. Recently, it could also be demonstrated that UBC9 can physically interact with ET...
The transcription factors , Jun, and Ets regulate the expression of and -1 genes. Recently, we found that , an Ets family member, activates -1 gene but not by physically interacting with c-/c-Jun. Interestingly, binds to promoter and represses its activation by . Here, to investigate the...
The PNT (or Pointed) domain, present within a subset of the Ets family of transcription factors, is structurally related to the larger group of SAM domains through a common tertiary arrangement of four α-helices. Previous studies have shown that, in contrast to the PNT domain from Tel, this...
Bcl-xL, a member of the Bcl-2 family, inhibits apoptosis, and its expression is regulated at the transcriptional level, yet nothing is known about the transcription factors specifically activating this promoter. The bcl-x promoter contains potential Ets binding sites, and we show that the transcr...
statistical methods and found that the CIS profile of ELs and T-ALLs differed markedly. Whereas Notch and Ikaros insertions were most common in T-ALL, ETS family transcription factors (ErgandEts1) were the most commonly activated genes in ELs and were activated in the almost all of these ...
In mammalian cells, TCF (Ternary Complex Factor) transcription factors belongs to the ets 1 family. They share through their ets DNA-binding domain (85 amino acids) the ability to bind to the Serum Responsive Element (SRE) when associated to SRF dimers (Serum Response factor). The ternary co...