Transcription factor effector domains. Subcell Biochem. 2011;52:261-77. 8. Gao J, Li WX, Feng SQ, Yuan YS, Wan DF, Han W, et al. A protein-protein interaction network of transcription factors acting during liver cell proliferation. Genomics. 2008;91(4):347-55....
Transcription factor effector domains. The last decade has seen an incredible breakthrough in technologies that allow histones, transcription factors (TFs), and RNA polymerases to be precisely m... Seth,Frietze,Peggy,... - Sub-cellular biochemistry 被引量: 21发表: 2011年 Compendium of human ...
J. Transcription factor effector domains. Subcell. Biochem. 52, 261–277 (2011). Article CAS PubMed PubMed Central Google Scholar McDonald, O. G., Wu, H., Timp, W., Doi, A. & Feinberg, A. P. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat. ...
Similarly, transcription effector domains fused to zinc- fingers targeting the epcam promoter modulated epcam promoter activity (Gommans et al, 2007). Recently, we showed that an EpCAM-specific triple helix-forming oligonucleotide coupled to a methyltransferase variant is able to target methylation ...
Transcription factor numbers We focused on ten major super-families of transcription factors: lambda repressor-like, C-terminal effector domain of the bipartite response regulators, winged helix, srf-like domains, DNA binding domain (GCC box), helix-loop-helix, Zn2/Cys6, glucocorticoid receptor-lik...
and with other transcription factors. The DNA-binding domains are typically highly conserved per family across the Animal Kingdom, while the effector domains evolve more rapidly. Transcription factors execute many functions as we shall see in the course of this book, includinggene activation,gene rep...
[194,195]. It is possible that the influence of FoxO3 activity differs with different stages of the disease. Interestingly, Vidal and colleagues unveiled a new mechanism of FoxO function in HD, where the loss of the unfolded protein response (UPR) transcription factor XBP1 leads to augmented ...
TRANSCRIPTIONFACTORANALYSISINPLANTA...132 InducibleGeneExpression...133 AViralVectorfortheEctopicExpressionofTranscriptionFactors...135 TRANSCRIPTIONFACTORDOMAINS...135 GeneFusionsfortheIdentificationofProteinDomains...135 NuclearLocalizationofTranscriptionFactors...136 PROTEIN-PROTEININTERACTIONS......
Since MLL fusion proteins lack the normal effector domains of the wild-type protein, they instead depend on the C-terminal fusion partner to activate transcription. AF4, AF9, ENL, and ELL are the most common fusion partners of MLL in leukemia, with each being a different subunit of the ...
Structures of YAP protein domains reveal promising targets for development of new cancer drugs YAP (Yes-associated protein) is a potent oncogene and a major effector of the mammalian Hippo tumor suppressor pathway. In this review, our emphasis is on ... M Sudol,DC Shields,A Farooq - 《Semina...