epitranscriptomemicroRNAsnoncoding RNAsStem cells (SCs) are unique cells that have an inherent ability to self-renew or differentiate. Both fate decisions are strongly regulated at the molecular level via intricate signaling pathways. The regulation of signaling networks promoting self-renewal or ...
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs derived from longer structured RNAs (for example, transfer, ribosomal, Y, small nucleolar, small nuclear and vault RNAs), ...
The world of small noncoding RNAs (sncRNAs) is ever-expanding, from small interfering RNA, microRNA and Piwi-interacting RNA to the recently emerging non-canonical sncRNAs derived from longer structured RNAs (for example, transfer, ribosomal, Y, small nucleolar, small nuclear and vault RNAs),...
17. Therefore, a better characterization of MPM pathogenesis and biological features is of the outmost importance. The dysregulation of small noncoding RNAs, specifically microRNAs (miRNAs, 18–22 nucleotides in length), plays a significant role in tumorigenesis, including melanoma onset and progression...
More information:Manel Esteller et al, The Epitranscriptome of Noncoding RNAs in Cancer,Cancer Discovery(2017).
We then discuss the major advancements in our understanding of the epitranscriptome in stem cell biology, especially embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). We also touch on how the epitranscriptome itself is regulated in embryonic stem cells. In addition, we ...
linear polymer of nucleotides found in the nucleus but mainly in the cytoplasm of a cell where it is associated with microsomes; it transmits genetic information from DNA to the cytoplasm and controls certain chemical processes in the cell; "ribonucleic acid is the genetic material of some ...
along with other abundant non-coding RNAs and a few of mRNAs [82,88,89]. The cancer stem cell functions are controlled by global protein synthesis, but NSUN2 depletion induces decreased m5C level of tRNA and inhibits this process [83]. In budding yeast, NOP2/NSUN1 is essential for ribo...
Welcome to 'The Epitranscriptome', an article collection from various Nature journals highlighting the role of mRNA modifications in RNA fate and gene expression.
Each cell in the human body has a distinguishable fate. Pluripotent stem cells are challenged with a myriad of lineage differentiation options. Defects are more likely to be fatal to stem cells than to somatic cells due to the broad impact of the former