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The genomes of plants encode three genes of the 95 kDa subunit (VHA-a) of the vacuolar type H+-ATPase. Immuno-localisation of VHA-a shows that the recognized subunit is exclusively located on the endoplasmic reticulum. This result is in agreement with the hypothesis that the different ...
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The direction of the reaction—synthesis or hydrolysis—depends on the specific enzyme and the cellular conditions. 8 The functions of ATPase and ATP Synthase are reflective of their roles in energy metabolism. ATPases are involved in a wide range of cellular functions, including muscle contraction...
Additionally, we could observe that carbon fixation was heterogeneous among cells, likely reflecting individual responses to different microscale gradients and/or metabolic feedbacks.24 A comparable stimulatory effect of VHA on photosynthetic O2 production has recently been reported for photosymbiotic coral,...
Summary Vps4 is a AAA ATPase that mediates endosomal membrane protein sorting. It is also a host factor hijacked by a diverse set of clinically important v... Michael,John,Landsberg,... - 《Structure》 被引量: 95发表: 2009年 Structural Characterization of the ATPase Reaction Cycle of Endoso...
Little is known about the roles of V-ATPase accessory proteins in development, but it is plausible that these factors modulate specific V-ATPase functions in specific cell types. To date, the functions of Atp6ap1 in development have not been analyzed in mouse because knockout embryonic stem ...
逆浓度梯度转运到密闭区,溶解无机矿物质,为水解酶如CAⅡ、CATK、MMPs等提供酸性环境,抑制VATPase a3转运蛋白已成为治疗骨质疏松症的新靶标;并深化对CAⅡ、CATK、MMPs等水解酶阻滞剂的认识,从而多渠道、多方位、多 靶点地拓展骨质疏松症的治疗。 关键词:VATPasea3;破骨细胞;骨质疏松症 Explorationofthemolecularmec...
What are the roles of different lysosomal movements and different lysosomal distributions in cancers? How are lysosomal movements and distributions regulated in cancer cells through conditions such as nutrient availability, extracellular pH changes and cellular stress? What effects do lysosomal movement and...