Schonbeck U, Libby P: The CD40/CD154 receptor/ligand dyad. Cell Mol Life Sci. 2001, 58: 4-43. 10.1007/PL00000776.Schonbeck U, Libby P (2001) The CD40/CD154 receptor/ligand dyad. Cell Mol Life Sci 58(1):4–43Schönbeck U, Libby P (2001) The CD40/CD154 receptor/dyad. Cell...
CD40 is a costimulatory member of the tumor necrosis factor receptor (TNFR) superfamily [2]. Along with its ligand (CD40L or CD154), CD40 is a transmembrane protein and, like other members of the TNFR superfamily, forms a trimer, with high order clustering of the protein required for ...
The CD40/CD154 receptor/ligand dyad. Cell Mol Life Sci 2001; 58: 4–43. Article CAS Google Scholar Peters AL, Stunz LL, Bishop GA . CD40 and autoimmunity: the dark side of a great activator. Semin Immunol 2009; 21: 293–300. Article CAS Google Scholar Dumas G, Dufresne M, ...
Libby The CD40/CD154 receptor/ligand dyad Cell Mol Life Sci, 58 (2001), pp. 4-43 View in ScopusGoogle Scholar 5 U. Schonbeck, N. Gerdes, N. Varo, et al. Oxidized low-density lipoprotein augments and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors limit CD40 and CD40L ...
CD45 is a protein tyrosine phosphatase receptor which negatively regulates CD40L-CD40-induced microglialM1activation; an effect leading to the promotion of anM2phenotype better suited to phagocytose and clear Aβ. Moreover, this CD45 mediated activation state appears to dampen harmful cytokine ...
CD40, a member of the tumour necrosis factor receptor (TNFR) superfamily, has the capacity to cause extensive apoptosis in carcinoma cells, while sparing normal epithelial cells. Yet, apoptosis is only achieved by membrane-presented CD40 ligand (mCD40L),
Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM Nature, 361 (1993), pp. 539-541 View in ScopusGoogle Scholar 3 U. Schonbeck, P. Libby The CD40/CD154 receptor/ligand dyad Cell Mol. Life Sci., 58 (2001), pp. 4-43 View in ScopusGoogle Scholar...
The co-stimulatory receptor, CD40 molecule, is a 50-kDa type I member of the tumor necrosis factor receptor superfamily that is widely expressed by the various immune and non-immune cells [1,2,3,4,5,6,7]. The interaction between CD40 and its ligand, CD40L (CD154), is one of multiple...
The T cell immunoglobulin domain and mucin domain 3 (TIM-3) is another negative regulatory receptor that was originally found on Th1 cells inducing tolerance through interaction with its ligand, galectin-9 [144], but later was detected on other T cells as well, including CD8 + T cells [145...
The disruption of the CD40-CD40L dyad in hyperlipidemic mice suppressed Th1 responses, particularly interferon (IFN)-γ expression, and reduced plaque burden [36]. Additional co-stimulatory molecules such as the glucocorticoid-induced tumor necrosis factor receptor (GITR) [37], CD27 [38], and ...