RecombiMAb anti-mouse CD40抗体是一种重组嵌合型单克隆抗体,它与小鼠CD40(也称为Bp50)反应。CD40是一种48 kDa的I型跨膜糖蛋白,属于肿瘤坏死因子受体(TNFR)超家族。这种抗体的可变结构域序列与原始FGK4.5克隆号相同,但恒定区序列已经从大鼠IgG2a变为小鼠IgG2a,且不包含Fc突变。 CD40在抗原呈递细胞(APCs)上广泛表...
YH008为全球首个PD-1/CD40双抗,与人PD-1和CD40有高度亲和力,Fc则引入LALA突变去除了Fceffector效应。YH008的分子设计效果为PD-1依赖性的CD40激活,从而改善了安全性并提高了疗效。 2022年AACR会议上,百奥赛图公布了YH008的临床前数据,体内研究表明YH008的设计达到了PD-1靶点和CD40靶点的协同治疗效应。 CD40抑制剂...
CD40 ligand, a type II transmembrane protein recently renamed CD154, was originally considered restricted to activated T lymphocytes, functioning as a mediator of T cell-dependent B cell activation, proliferation, and differentiation. However, the spectrum of CD154 expression and function has broadened...
Through its binding to CD40 on antigen presenting cells (APC) including B cells, monocytes/macrophages, and dendritic cells, it serves a crucial function in T cell-APC cognate interaction. CD154-interaction with CD40 transduces signals for T-dependent B cell activation and induces B cells...
蛋白别名:CD154; CD40 antigen ligand; CD40 ligand; CD40-L; H-CD-40-L; M-CD-40-L; RP23-153G22.3; T-B cell-activating molecule; T-cell antigen Gp39; TNF-related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; Tumor necrosis factor ligand superfamily member...
CD40, a member of the nerve growth factor/tumor necrosis factor receptor superfamily, and its ligand, CD154, play essential roles in cell immune responses.
CD40一CD154可能通过影响免疫功能及加速肾脏损伤参与了尿毒症的发生发展,阻断 CD40一CD154相互作用可能有助于延缓疾病进程。 【关键词】血液透析;CD40;13I)40配体 · 363 · ·论著· . It—el|h晔 ofpI姗 solullleCD40mdCD154011CD4+Tcellsofhmnoaialy~sp旧鼬 ...
cells including B cells, monocytes/macrophages and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. CD154 interaction with CD40 transduces signals for T-dependent B-cell activation and induces B cell cycle entry. 24-31 cross-reacts with the cynomolgus monkey CD154....
抗体名: Anti-Human CD154/CD40LG/TNFSF5 Antibody (5C8)(流式抗体) 亚型: IgG1, kappa 浓度: 1 mg/ml % 是否单克隆: 是 靶点: CD154/CD40LG/TNFSF5 免疫原: Mouse 宿主: Mouse 用途: 仅用于科研 保质期: 1 year 应用范围: FCM 产地: France 标记物: Unconjugate 品牌: Antibo...
CD40是一个完整的Ⅰ型膜糖蛋白,属TNF受体超家族的成员,主要表达于抗原提呈细胞(APC)上.CD154是CD40的配体,为二型跨膜糖蛋白,属TNF超家族成员,主要表达于活化的CIM^+ T细胞.CD154-CD40的相互作用可以调节Th1/Th2型免疫应答.最近的研究显示CD40-CD154的相互作用在调节宿主对寄生虫感染免疫中起着重要的作用.尤其...