aThis theory came under scrutiny as scientists began to unravel the causes of insulin resistance, demonstrating that fat deposition in muscle, liver, and the abdomen can cause insulin resistance and the other abnormalities associated with the metabolic syndrome, particularly inflammation. 这种理论受到察...
aThis theory came under scrutiny as scientists began to unravel the causes of insulin resistance, demonstrat- ing that fat deposition in muscle, liver, and the abdomen can cause insulin resistance and the other abnormalities associated with the metabolic syndrome, particularly inflammation 这种理论受到...
Tchernof, AndréDesprés, JeanPierreMittelman, Steven DCitters, Gregg W VanFerrannini E (2006). Is insulin resistance the cause of the metabolic syndrome? Ann Med 38, 42-51.Ferrannini E. Is insulin resistance the cause of the metabolic syndrome[J].Annals of Medicine,2006,(01):42-51....
The primary cause of insulin resistance is the positive energy imbalance due to overeating and/or lack of physical activities. However, the primary player that converts the positive energy imbalance into insulin resistance and the consequent hyperin-sulinemia is still hotly debated. Establishment of...
[2004]). Furthermore, elevated expression of ROS has been linked to downregulation of IGF-1 signalling and induction of insulin resistance (Bashan et al.,[2009]). The damaging effect of elevations in free radical expressi...
Insulin resistance in obesity as the underlying cause for the metabolic syndrome. The metabolic syndrome affects more than a third of the US population, predisposing to the development of type 2 diabetes and cardiovascular disease. The 2... EJ Gallagher,D Leroith,E Karnieli - 《Mount Sinai Jou...
For many years, cardiovascular disease (CVD) has been the leading cause of death around the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid profiles and insulin resistance. Insulin is a key hormone that functions as a regulator of cellular metabolism in many tis...
Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Recent studies have demonstrated that reduced insulin-stimulated muscle glycogen synthesis is the major cause of insulin resistance in patients with non-in... C,N,Hales,... - 《International Journal of Epidemiology》...
Background & aims: In elective surgery, postoperative hyperglycaemia and insulin resistance are inde- pendent risk factors for complications. Since the simpler HOMA method has been used as an alternative to the hyperinsulinemic normoglycemic clamp in studies of surgery induced insulin resistance, we ...
(HOMA) which suggested that in this cohort of subjects with recently diagnosed Type 2 diabetes, an ongoing decline in beta-cell function without a change in insulin sensitivity was occurring [17,18]. The underlying cause of the progression from IGT to diabetes in subjects in the DPP has not...