In the presence of calcium, these RTX motifs are able to fold into an idiosyncratic structure called the parallel 尾-roll. The adenylate cyclase toxin (CyaA) produced by Bordetella pertussis, the causative agent of whooping cough, is one of the best-characterized RTX cytolysins. CyaA contains...
Bordetella pertussis, the causative agent of whooping cough, produces an acute and chronic respiratory infection in infants and young children. B. pertussis is still a major health problem of young children throughout the world even though effective immunization against whooping cough is available. Whi...
Bordetella pertussis is the causative agent of whooping cough or pertussis, a serious respiratory disease (see ref. 1 for an excellent review). The first step in the pathogenesis of pertussis is adherence of the bacteria to the respiratory tract, and two classes of bacterial proteins are ...
The causative agent of whooping cough, pertussis toxin causes the persistent activation of Gi proteins by catalysing the ADP-ribosylation of the α-subunit. PDZ DOMAIN A peptide-binding domain that is important for the organization of membrane proteins, particularly at cell–cell junctions, including...
Any of various small, gram-negative coccobacilli of the genusBordetella,some of which are pathogenic in the human respiratory tract. It includesB. pertussis,the causative agent of whooping cough. [New LatinBordetella,genus name, after Jules Jean Baptiste VincentBordet(1870-1961), Belgian bacteriolo...
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Bordetella pertussis is the causative agent of whooping cough, a contagious childhood respiratory disease. Increasing public concern over the safety of whole-cell vaccines led to decreased immunisation rates and a subsequent increase in the incidence of the disease. Research into the development of safe...
Bordetella bronchiseptica is a respiratory pathogen that is closely related to Bordetella pertussis and Bordetella parapertussis, the causative agents of whooping cough in humans [9, 10]. B. bronchiseptica causes a range of diseases in various mammals that can be chronic, difficult to completely eradi...
Bordetella pertussis, the causative agent of whooping cough, secretes among other virulence factors an adenylate cyclase (AC) toxin that is able to enter into eukaryotic cells where it is activated upon binding to endogenous calmodulin (CaM) and synthesizes supraphysiological cAMP levels. In vivo, ...
PERTUSSIS TOXIN The causative agent of whooping cough, pertussis toxin causes the persistent inactivation of Gi proteins by catalysing the ADP- ribosylation of the α-subunit. NT Trk Nogo-66 Omgp Mag Ngr db-cAMP p75NTR cAMP PKA Gi C3 Rho ROCK MLCK MLC Transcription Nucleus ArgI Cytoskeletal ...