The infection triggers the host immune response, and both can cause vascular endothelial damage, interrupting tight junctions proteins; consequently, the blood-brain barrier (BBB) breaks down, allowing and facilitating the entry of peripheral immune cells into the brain, which triggers or exacerbates...
Blood-brain barrier dysfunction in Binswanger's disease; an immunohistochemical study Binswanger's disease is pathologically characterized by a combination of diffuse cerebrovascular white matter lesions and lacunar infarcts in the basal gan... I.,Akiguchi,Hidekazu,... - 《Acta Neuropathologica》 被引...
This biomarker could, therefore, reflect glial cell injury and the blood-brain barrier destruction in sepsis. A growing number of studies have suggested that increased serum S100B levels are associated with brain dysfunction in sepsis patients20,21,22. However, other studies have also shown that ...
In the brain, several routes for viral entry have been proposed, including the olfactory nerve, the choroid plexus and the blood–brain barrier (BBB). The role of the BBB appears to be of utmost relevance, given that SARS-CoV-2 can be found free in the bloodstream [1] suggesting that v...
The physiological response of this sepsis-induced systemic inflammation can affect blood–brain barrier (BBB) function; subsequently, endothelial cells produce inflammatory mediators, including cytokines, chemokines, and matrix metalloproteinases (MMPs) that degrade tight junction (TJ) proteins and decrease ...
The blood-spinal cord barrier in health and disease BSCB architecture The BSCB is generally considered to be an extension of the blood brain barrier (BBB). They share the same ultrastructural arrangement, although differences in morphology and function do exist as will be discussed in the following...
Low folate level may be due to decreased folate intake/absorption; loss of blood brain barrier transport of folate due to inflammation; mutations in the genes that encodes proteins in folate transporters and carriers, such as folate receptor alpha (FR∝), proton-coupled folate transporter (PCFT)...
Influence of age on the passage of paraquat through the blood-brain barrier in rats: a distribution and pathological examination. Hum Exp Toxicol 1996;15:231–236. CAS PubMed Google Scholar Bartlett RM, Holden JE, Nickles RJ et al. Paraquat is excluded by the blood brain barrier in ...
The vascular blood-brain barrier (BBB) protects the central nervous system from blood-borne substances that are otherwise neurotoxic. Inflammation has long been known to disrupt the BBB. Skoog in 1937 found that an allergic reaction could disrupt the BBB [1]. Meningitis, encephalitis, sepsis, and...
The blood–brain barrier (BBB) is a unique microvascular structure that forms the major interface between central nervous system (CNS) interstitial fluids and the circulating blood. BBB disruption induces blood-derived neurotoxic proteins accumulation in the CNS, resulting in initiating and/or contributi...