Not only cognitive deficits but also anxiety, depression, and post-traumatic stress disorder are common in severe sepsis survivors. In this study, we demonstrated that amitriptyline, a classic tricyclic antidepressant, reduced sepsis-induced brain damage through the tropomyosin receptor kinase A (TrkA)...
potentially increasing the brain's vulnerability to the development of dementia later in life [6,7]. Sepsis triggers the host immune response causing vascular endothelial damage; consequently, the blood–brain barrier (BBB) breaks down, allowing...
Sepsis is a severe body response to infection, which causes the immune system to attack tissues and leads to inflammation and potential organ damage. It can advance to septic shock with dangerously low blood pressure and organ failure. Common causes of sepsis include pneumonia, urinary tract infect...
The activated microglia and astrocytes release reactive oxygen species (ROS), cytokines, chemokines, and neurochemicals, initiate mitochondrial dysfunction and neuronal damage, and exacerbate the inflammatory milieu in the brain. These changes trigger sepsis-associated encephalopathy (SAE), which has the ...
University Hospitals Coventry & Warwickshire Trust's negligent delay treating sepsis caused brain damage to premature baby Samantha Critchley After taking over the case from another law firm, Samantha secured judgment on behalf of Baby X who was an extremely premature baby under the care of t...
Sepsis is life-threatening and often leads to acute brain damage. Dexmedetomidine, an α2-adrenoceptor agonist, has been reported to possess neuroprotective effects against various brain injury but underlying mechanisms remain elusive. In this study, in vitro and in vivo models of sepsis were used ...
Systemic sepsis commonly produces brain dysfunction, sepsis-associated encephalopathy, which can vary from a transient, reversible encephalopathy to irreversible brain damage. The encephalopathy in the acute phase clinically resembles ma... Y Oda 被引量: 8发表: 2015年 Potential Neuroprotective Role of ...
sepsis—inducedbraindamageviatheinhibitionoftoll-likereceptor4.tumOrnecrosisfactora.and interleukin-6expression. KeyWords:braindamage;Januskinaseandsignaltransducerandactivatoroftranscription; sepsis;signaltransductionpathway;Toll·likereceptor4 INTRODUCTlON ThecelluIarandmolecularmechanisms underlyingsepsis—inducedbrain...
Thus, we here summarize the current knowledge on the role of free radicals in the development of brain dysfunction in sepsis focusing on oxidative damage and the redox control of brain inflammatory pathways. This is a preview of subscription content, log in via an institution to check access. ...
and brainetc.Thus, MDSCs are increased in circulation, bone marrow, spleen, and lymph nodes. MDSCs secrete various immunosuppressive molecules including IL-10 and TGF-β, mentioned in text in detail to exert their immunosuppressive action on CD4+, CD8+T cells as well as polarizing them to ex...