In parallel, damage within autonomic nervous and neuroendocrine systems may contribute to sepsis induced organ dysfunction.doi:10.1186/cc2951Tarek SharsharAttending Physician, Service de Réanimation Médicale, Hôpital Raymond Poincaré, Université de Versailles Saint-Quentin-en-Yvelines, Garches, France...
Thus, we here summarize the current knowledge on the role of free radicals in the development of brain dysfunction in sepsis focusing on oxidative damage and the redox control of brain inflammatory pathways. This is a preview of subscription content, log in via an institution to check access. ...
The activated microglia and astrocytes release reactive oxygen species (ROS), cytokines, chemokines, and neurochemicals, initiate mitochondrial dysfunction and neuronal damage, and exacerbate the inflammatory milieu in the brain. These changes trigger sepsis-associated encephalopathy (SAE), which has the ...
Sepsis is life-threatening and often leads to acute brain damage. Dexmedetomidine, an α2-adrenoceptor agonist, has been reported to possess neuroprotective effects against various brain injury but underlying mechanisms remain elusive. In this study, in vitro and in vivo models of sepsis were used ...
[6,7]. Sepsis triggers the host immune response causing vascular endothelial damage; consequently, the blood–brain barrier (BBB) breaks down, allowing and facilitating the entry of peripheral immune cells into the brain, which triggers or exacerbates glial cell activation and neuroinflammation [8]...
Ethyl pyruvate (EP) is a simple aliphatic ester of pyruvic acid and has been reported to mitigate the damage caused by various stressors, such as, hemorrhagic shock, stroke, sepsis, and acute pancreatitis1–4. Accumulating evidences indicates EP is a multi-functional protective agent that ...
Sepsis is the most common cause of acute respiratory distress syndrome, a severe lung inflammatory disorder with an elevated morbidity and mortality. Sepsis and acute respiratory distress syndrome involve the release of inflammatory mediators to the systemic circulation, propagating the cellular and molecul...
Sepsis survivors often display long-term cognitive impairments indicating a chronic brain damage despite recovery from the initial septic insult [9]. Numerous mechanisms triggered by sepsis have been proposed to underlie SAE, yet its ontogeny is complex and remains enigmatic. Intuitively, altered ...
The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) are important for the maintenance of brain homeostasis. During sepsis, peri
Sepsis-associated encephalopathy is a common neurological complication of sepsis and is responsible for higher mortality and poorer long-term outcomes in septic patients. Sepsis-associated encephalopathy symptoms can range from mild delirium to deep coma, which occurs in up to 70% of patients in inten...