The biogenesis of nascent circular RNAs. Cell Rep. 15, 611–624 (2016). Article CAS PubMed Google Scholar Huang, C., Liang, D., Tatomer, D. C. & Wilusz, J. E. A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs. Genes Dev. 32, 639–644 (...
The biogenesis of nascent circular RNAs. Cell Rep. 15, 611–624 (2016). CAS PubMed Google Scholar Enuka, Y. et al. Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor. Nucleic Acids Res. 44, 1370–1383 (2016). CAS PubMed Google ...
In this case, it remains unclear how the spliceosome could specifically recognize these exons for circular but not linear RNAs. Regulation of circRNA Biogenesis By a broader definition, back-splicing circularization is an additional type of alternative splicing. Recent data have shown that back-...
The biogenesis and classification of tsRNAs Human tRNA genes synthesize pre-tRNA through the action of RNA pol-III. Subsequently, pre-tRNA undergoes processing by RNase P and RNase Z processing to excise its 5’ and 3’ ends, respectively, and tRNA splicing endonuclease removes introns from pre-...
MicroRNAs (miRNAs) are small, yet profoundly influential, non-coding RNAs that base-pair with mRNAs to induce RNA silencing. Although the basic principles of miRNA biogenesis and function have been established, recent breakthroughs have yielded important new insights into the molecular mechanisms of mi...
(CTGS). The coupling of repressive epigenetic modification with transcription by an RNA polymerase that produces a nascent RNA molecule targeted by small RNAs. Pericentromeric regions Sites of constitutive heterochromatin that flank the central kinetochore-binding region of the centromere and are necessary...
the downregulated promoters, their relationship to nitrogen is a little more complex. SSb2p (RTBOTA2_000530) is a ribosome-associated chaperone that has been suggested to control ribosome biogenesis inS. cerevisiae[52], and downregulation of ribosomal biogenesis genes has been observed during ...
Here, using cryo-EM of yeast CPF, we show that the Mpe1 subunit directly contacts the polyadenylation signal sequence in nascent pre-mRNA. The region of Mpe1 that contacts RNA also promotes the activation of CPF endonuclease activity and controls polyadenylation. The Cft2 subunit of CPF ...
The biogenesis, functions, and challenges of circular RNAs. Mol. Cell 71, 428–442 (2018). Article CAS PubMed Google Scholar Zhang, Y. et al. The biogenesis of nascent circular RNAs. Cell Rep. 15, 611–624 (2016). Article CAS PubMed Google Scholar Kushawah, G. et al. CRISPR-...
Biogenesis, functions and clinical significance of circRNAs in gastric cancer. Mol. Cancer 18, 136 (2019). Article PubMed PubMed Central Google Scholar Zhang, Y. et al. The biogenesis of nascent circular RNAs. Cell Rep. 15, 611–624 (2016). Article CAS PubMed Google Scholar Haque, S...